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117620-84-5

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117620-84-5 Structure

117620-84-5 Structure
IdentificationBack Directory
[Name]

(3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
[CAS]

117620-84-5
[Synonyms]

Levofloxacin-10
Levofloacin Impurity 8
Levofloacin Impurity J
Levofloxacin Impurity J
Levofloxacin Impurity 2
Levofloxacin Impurity 43
(S)-10-fluoro-3-methyl-7-oxo
(S)-10-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
(3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 10-fluoro-2,3-dihydro-3-methyl-7-oxo-, (3S)-
Levofloxacin (3S)-10-Fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
Levofloxacin impurity 12/(3S)-10-Fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
[Molecular Formula]

C13H10FNO4
[MDL Number]

MFCD31579563
[MOL File]

117620-84-5.mol
[Molecular Weight]

263.221
Chemical PropertiesBack Directory
[solubility ]

Methanol
[form ]

Solid
[color ]

White
Hazard InformationBack Directory
[Uses]

(3S)-10-Fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid is an intermediate in the synthesis of Levofloxacin (L360000), an antibiotic used against gram-negative organisms.
[Synthesis]

(3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid is synthesized by reacting ethyl (S)-10-fluoro-3-methyl-7-oxo- 2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylate with Potassium hydroxide in Tetrahydrofuran by reflux.1
(3S)-10-Fluoro-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
[References]

[1] JEFFREY L. GRAY. Synthesis and Biological Testing of Non-Fluorinated Analogues of Levofloxacin.[J]. ChemInform, 2003, 34 42. DOI:10.1002/chin.200342162.
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