| Identification | Back Directory | [Name]
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride | [CAS]
1177141-67-1 | [Synonyms]
CKI-7 dihydrochlorid
CKI-7 Dihydrochloride
N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide Dihydrochloride | [Molecular Formula]
C11H14Cl3N3O2S | [MDL Number]
MFCD00897689 | [MOL File]
1177141-67-1.mol | [Molecular Weight]
358.672 |
| Chemical Properties | Back Directory | [Appearance]
Beige Solid | [Melting point ]
187-189°C | [storage temp. ]
-20°C Freezer | [solubility ]
H2O: >5mg/mL | [form ]
solid | [color ]
white to light tan | [Water Solubility ]
H2O: >5mg/mL | [InChI]
1S/C11H12ClN3O2S.2ClH/c12-10-1-2-11(18(16,17)15-6-4-13)9-7-14-5-3-8(9)10;;/h1-3,5,7,15H,4,6,13H2;2*1H | [InChIKey]
JUAVTXYOCISSSL-UHFFFAOYSA-N | [SMILES]
Cl[H].Cl[H].NCCNS(=O)(=O)c1ccc(Cl)c2ccncc12 |
| Hazard Information | Back Directory | [Chemical Properties]
Beige Solid | [Uses]
Found to have a potent inhibitory action against casein kinase 1 completely with respect to ATP and a much weaker effect on casein kinase 2 and other protein kinases | [Biochem/physiol Actions]
CKI-7 is a CK1 inhibitor; also inhibits SGK, S6K1 and MSK1. CKI-7 inhibits SGK as potently as CK1. IC50 = 6 μM. | [in vivo]
In vivo dose-dependent anti-tumor activity of CKI-7 is demonstrated in a SCID-Beige mouse systemic tumor model utilzing a recently isolated Philadelphia chromosome positive acute lymphoblastic leukemia cell line. Standard cell cycle synchronization studies established that exposure to CKI-7 results in cell cycle dependent caspase 3 activation and apoptotic cell death[2]. | [IC 50]
CK1: 6 μM (IC50); p70S6K; CK1: 8.5 μM (Ki); Cdc7; SGK; MSK1 | [storage]
Store at -20°C |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
45 | [RIDADR ]
UN 2811 6.1 / PGIII | [WGK Germany ]
3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 3 Oral |
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Website: |
https://www.bocsci.com |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
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