| Identification | More | [Name]
2-Amino-thiazole-4-carboxylic acid methyl ester | [CAS]
118452-04-3 | [Synonyms]
2-amino-thiazole-4-carboxylic acid methyl ester
AURORA KA-222
METHYL 2-AMINO-1,3-THIAZOLE-4-CARBOXYLATE
METHYL 2-AMINOTHIAZOLE-4-CARBOXYLATE
Methyl 2-Aminothioazole-4-carboxylate
Methyl-2-amino
Methyl 2-amino-4-thiazoleformate
Methyl 2-aminothiazole-4-carboxylate ,99% | [EINECS(EC#)]
692-464-1 | [Molecular Formula]
C5H6N2O2S | [MDL Number]
MFCD00622441 | [Molecular Weight]
158.18 | [MOL File]
118452-04-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Yellow Solid | [Melting point ]
160-164 | [Boiling point ]
298.7±13.0 °C(Predicted) | [density ]
1.408±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
Water | [form ]
Solid | [pka]
2.46±0.10(Predicted) | [color ]
Yellow | [Detection Methods]
HPLC,NMR | [InChI]
InChI=1S/C5H6N2O2S/c1-9-4(8)3-2-10-5(6)7-3/h2H,1H3,(H2,6,7) | [InChIKey]
WYVZZWKIKAKUKV-UHFFFAOYSA-N | [SMILES]
S1C=C(C(OC)=O)N=C1N | [CAS DataBase Reference]
118452-04-3(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
Methyl 2-Aminothioazole-4-carboxylate (cas# 118452-04-3) is a compound useful in organic synthesis. | [Synthesis]
A solution of methyl 3-bromo-2-oxo-propanoate (10 g, 51 mmol) and thiourea (4.0 g, 552 mmol) in EtOH (200 mL) was added CuOAc (0.3 g, 2.62 mmol), then stirred at room temperature for 10 h. The mixture was concentrated to give the crude product (16 g). The crude product was basified with NaHC03 to pH=8, then extracted with EtOAc (200 mL x 3). The organic layer was washed with H20 (100 mL) and brine (100 mL), and then dried over anhydrous Na2S04, and then concentrated to give the product Methyl 2-Aminothiazole-4-carboxylate (8.0 g) as a yellow solid.
| [References]
[1] Synthesis (Germany), 2013, vol. 45, # 10, p. 1300 - 1311
[2] Justus Liebigs Annalen der Chemie, 1951, vol. 571, p. 44,55
[3] Patent: WO2014/37480, 2014, A1. Location in patent: Page/Page column 125
[4] Patent: US2015/31687, 2015, A1. Location in patent: Paragraph 0439; 0440 |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
| Company Name: |
ZEROSCHEM.CO.,LTD.
|
| Telephone: |
10-61256048 13810278579; |
| Website: |
http://www.zeroschem.com |
|