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77521-29-0

77521-29-0 Structure

77521-29-0 Structure
IdentificationBack Directory
[Name]

(RS)-AMPA
[CAS]

77521-29-0
[Synonyms]

AMPA
C13672
AMPA HBR
(RS)-AMPA
AMPA (ZWITTERION) POTENT EXCITATORY AMI
5-Methyl-3-hydroxy-α-aminoisoxazole-4-propionic acid
2-AMINO-3-(3-HYDROXY-5-METHYLISOXAZOL-4-YL)PROPANOIC ACID
2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propanoic acid
(R,S)-A-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
2-Amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)-propionic acid
α-Amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid
(RS)-ALFA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
(RS)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
(S)-2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid
(+/-)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID
(R,S)-2-AMINO-3-(3-HYDROXY-5-METHYL-4-ISOXAZOLYL)PROPIONIC ACID
(±)-α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid hydrobromide
(r,s)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid, Hydrobromide
(RS)-alpha-Amino-3-hydroxy-5-methyl-4-isoxazol-propionic acid hydrobromide
[Molecular Formula]

C7H10N2O4
[MDL Number]

MFCD00069214
[MOL File]

77521-29-0.mol
[Molecular Weight]

186.17
Chemical PropertiesBack Directory
[Appearance]

White-to-Off White Powder
[Melting point ]

240 °C
[density ]

1.386±0.06 g/cm3(Predicted)
[storage temp. ]

2-8°C
[solubility ]

H2O: 1.2 mg/mL
[form ]

solid
[pka]

2.15±0.10(Predicted)
[color ]

white
[Water Solubility ]

Soluble in water (10mM, gentle warming)
[Stability:]

Hygroscopic
[CAS DataBase Reference]

77521-29-0
[EPA Substance Registry System]

.alpha.-Amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (77521-29-0)
Hazard InformationBack Directory
[Chemical Properties]

White-to-Off White Powder
[Uses]

A potent and selective agonist of the excitatory neurotransmitter L-glutamic Acid. AMPA does not interfere with binding sites for kainic acid in vitro, and AMPA- induced neuronal excitation is not significantly affected by NMDA antagonists
[Uses]

AMPA is the defining agonist for the AMPA subgroup of ionotropic glutamate receptors, which mediate excitatory neurotransmission. Because AMPA does not interfere with binding sites for kainic acid or NMDA , it can be used to distinguish AMPA receptor-specific activity that contributes to a neuronal response. (R,S)-AMPA contains an equal mixture of the active (S)-enantiomer and the inactive (R)-enantiomer.
[Biological Activity]

More water soluble hydrobromide salt of ( RS )-AMPA ((RS)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionicacid ).
[Definition]

ChEBI: (S)-AMPA is a non-proteinogenic alpha-amino acid.
[storage]

Room temperature
Safety DataBack Directory
[WGK Germany ]

3
[HS Code ]

2934999090
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