| Identification | More | [Name]
(S)-1-N-Boc-2-(aminomethyl)pyrrolidine | [CAS]
119020-01-8 | [Synonyms]
(2S)-2-AMINOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
RARECHEM AL BW 2320
(S)-1-BOC-2-(AMINOMETHYL)PYRROLIDINE
(S)-1-N-Boc-2-(aminomethyl)pyrrolidine
(S)-2-AMINOMETHYL-1-BOC-PYRROLIDINE
(S)-2-(AMINOMETHYL)-1-N-BOC-PYRROLIDINE
(S)-2-AMINOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(S)-TERT-BUTYL-2-(AMINOMETHYL)PYRROLIDINE-1-CARBOXYLATE
tert-Butyl 2-(1-aminoethyl)-1-pyrrolidinecarboxylate
(S)-N'-BOC-2-Aminomethylpirrolidine
(S)-2-(AMINOMETHYL)-1-N-BOC-PYYROLIDINE
(S)-2-(Aminomethyl)pyrrolidine, N1-BOC protected | [EINECS(EC#)]
251-228-4 | [Molecular Formula]
C10H20N2O2 | [MDL Number]
MFCD03419257 | [Molecular Weight]
200.28 | [MOL File]
119020-01-8.mol |
| Chemical Properties | Back Directory | [Boiling point ]
98-112℃/1mm | [density ]
1.044±0.06 g/cm3(Predicted) | [refractive index ]
1.4670-1.4710 | [storage temp. ]
2-8°C | [solubility ]
Miscible with N-methylpyrrolidinone. | [form ]
clear liquid | [pka]
9.91±0.29(Predicted) | [color ]
Colorless to Almost colorless | [BRN ]
8905233 | [InChI]
1S/C10H20N2O2/c1-10(2,3)14-9(13)12-6-4-5-8(12)7-11/h8H,4-7,11H2,1-3H3/t8-/m0/s1 | [InChIKey]
SOGXYCNKQQJEED-QMMMGPOBSA-N | [SMILES]
CC(C)(C)OC(=O)N1CCC[C@H]1CN | [CAS DataBase Reference]
119020-01-8(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
3259 | [WGK Germany ]
3 | [HazardClass ]
8 | [PackingGroup ]
Ⅲ | [HS Code ]
29339900 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Acute Tox. 4 Oral
Skin Corr. 1B |
| Hazard Information | Back Directory | [Description]
(S)-2-(Aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine is an optically active compound primarily used in organic synthesis for preparing small-molecule protein synthesis regulators or molecular glue degraders. | [Chemical Properties]
Solid | [Uses]
(S)-2-Aminomethyl-1-Boc-pyrrolidine acts as an intermediate in organic synthesis. It is also used as a chiral and heterocyclic building block in synthetic chemistry. | [Synthesis]
GENERAL METHOD: Under stirring conditions, azide derivatives 9a or 9b (4.03 mmol) were dissolved in THF (1 mL), followed by the addition of solid triphenylphosphine (Ph3P, 4.03 mmol) and water (H2O, 6.04 mmol). The reaction mixture was stirred continuously for 12 h at room temperature. After completion of the reaction, the solvent was removed by concentration under reduced pressure. The crude product was purified by rapid column chromatography on silica gel with an eluent ratio of methanol-dichloromethane (9:1). | [References]
[1] Synthesis, 2005, # 14, p. 2407 - 2413
[2] Angewandte Chemie - International Edition, 2011, vol. 50, # 48, p. 11382 - 11385
[3] Synthetic Communications, 2011, vol. 41, # 17, p. 2517 - 2523
[4] Tetrahedron Letters, 2010, vol. 51, # 40, p. 5281 - 5286
[5] Phosphorus, Sulfur and Silicon and the Related Elements, 2013, vol. 188, # 4, p. 509 - 511 |
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