| Identification | Back Directory | [Name]
N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide | [CAS]
1190378-57-4 | [Synonyms]
CS-2840
MRT67307
MRT68921
MRT67307 HCl
MRT67307 (free base)
MRT67307 hydrochloride
IKKε/TBK1 Inhibitor II, MRT67307 - CAS 1190378-57-4 - Calbiochem
N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide
Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-
N-[3-[[5-Cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]-cyclobutanecarboxamide hydrochloride | [Molecular Formula]
C26H36N6O2 | [MDL Number]
MFCD19443643 | [MOL File]
1190378-57-4.mol | [Molecular Weight]
464.6 |
| Chemical Properties | Back Directory | [density ]
1.270 | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
H2O: soluble15mg/mL, clear | [form ]
powder | [pka]
15.94±0.20(Predicted) | [color ]
white to light brown | [InChIKey]
UKBGBACORPRCGG-UHFFFAOYSA-N |
| Hazard Information | Back Directory | [Uses]
MRT67307 hydrochloride has been used to study its effect on LPS (lipopolysaccharide) -induced lysosome tubulation. | [Definition]
ChEBI: N-[3-[[5-cyclopropyl-2-[3-(4-morpholinylmethyl)anilino]-4-pyrimidinyl]amino]propyl]cyclobutanecarboxamide is an aromatic amine. | [Biochem/physiol Actions]
MRT67307 is an amino-pyrimidine derivative and has an IC50 value of 19. It is known to induce TLR (toll like receptor) mediated anti inflammatory cytokine generation. Also, MRT67307 prevents the secretion of cytokines associated with proinflammation. | [target]
IKKe | [storage]
Store at -20°C |
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