| Identification | Back Directory | [Name]
Propargyl-PEG6-azide | [CAS]
1198080-03-3 | [Synonyms]
Propargyl-PEG6-N3
Propargyl-PEG6-azide
Azido-PEG6-propargyl | [Molecular Formula]
C15H27N3O6 | [MDL Number]
MFCD31561110 | [MOL File]
1198080-03-3.mol | [Molecular Weight]
345.4 |
| Hazard Information | Back Directory | [Uses]
Propargyl-PEG6-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG6-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [Biological Activity]
Propargyl-PEG6-N3 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
|
| Company Name: |
Wuhan Topule
|
| Telephone: |
+86-02787215551 19945035818 |
| Website: |
http://www.topule.com/ |
|