| Identification | Back Directory | [Name]
Propargyl-PEG6-NHS ester | [CAS]
2093153-99-0 | [Synonyms]
2093153-99-0
Propargyl-PEG6-NHS ester
Propargyl-PEG5-CH2CH2COONHS
2,5-Dioxopyrrolidin-1-yl?4,7,10,13,16,19-hexaoxadocos-21-yn-1-oate | [Molecular Formula]
C20H31NO10 | [MDL Number]
MFCD29041935 | [MOL File]
2093153-99-0.mol | [Molecular Weight]
445.46 |
| Hazard Information | Back Directory | [Description]
Propargyl-PEG6-NHS ester is an amine reactive linker. The alkyne in this linker can react with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reaction. The PEG spacer increases solubility of the molecule in aqueous media. | [Uses]
Propargyl-PEG6-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG6-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. Propargyl-PEG6-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [IC 50]
Cleavable Linker; PEGs; Alkyl/ether | [References]
[1] Anandan Palani, et al. Insulin-incretin conjugates. WO2017160669A1. |
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