| Identification | More | [Name]
3,4-Dimethoxyphenethylamine | [CAS]
120-20-7 | [Synonyms]
2-(3,4-DIMETHOXYPHENYL)ETHYLAMINE
3,4-DIMETHOXYPHENETHYLAMINE
3,4-DIMETHOXY PHENYLETHYLAMINE
3,4-DIMETHYLOXYPHENYLETHYLAMINE
AKOS 235-24
AKOS BBS-00003591
AKOS NCG1-0105
AURORA KA-7640
B-(3,4-DIMETHOXYPHENYL)ETHYL AMINE
BETA-(3,4-DIMETHOXYPHENYL)-ETHYLAMINE
dmpea
HOMOVERATRYLAMINE
HVTA
RARECHEM AL BW 0210
TIMTEC-BB SBB008220
,4-Dimethoxypheneethylamine
2-(3,4-Dimethoxyphenyl)ethanamine
3,4-dimethoxy-benzeneethanamin
3,4-Dimethoxybenzeneethanamine
3,4-dimethoxy-Benzeneethanamine | [EINECS(EC#)]
204-376-9 | [Molecular Formula]
C10H15NO2 | [MDL Number]
MFCD00008188 | [Molecular Weight]
181.23 | [MOL File]
120-20-7.mol |
| Chemical Properties | Back Directory | [Appearance]
clear yellowish oil | [Melting point ]
12-15 °C
| [Boiling point ]
188 °C15 mm Hg(lit.)
| [density ]
1.074 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.348-0.348Pa at 25℃ | [refractive index ]
n20/D 1.546(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Refrigerator | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Viscous Liquid | [pka]
9.74±0.10(Predicted) | [color ]
Clear light yellow to orange or slightly brownish | [Specific Gravity]
1.10 | [PH]
11.4 (100g/l, H2O, 20℃) | [explosive limit]
0.1-1.7%(V) | [Water Solubility ]
SOLUBLE | [Sensitive ]
Air Sensitive | [InChIKey]
ANOUKFYBOAKOIR-UHFFFAOYSA-N | [LogP]
0.77 | [CAS DataBase Reference]
120-20-7(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzeneethanamine, 3,4-dimethoxy-(120-20-7) | [EPA Substance Registry System]
120-20-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
UN 2735 | [WGK Germany ]
3
| [RTECS ]
SH2300000
| [F ]
10 | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29222900 | [Safety Profile]
Poison by intravenous
and intraperitoneal routes. When heated to
decomposition it emits toxic fumes of NOx. | [Toxicity]
mouse,LD50,intraperitoneal,181mg/kg (181mg/kg),Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977. |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
(3,4-Dimethoxyphenyl)acetonitrile | [Preparation Products]
Verapamil-->Fenoldopam-->DOPEXAMINE-->DOBUTAMINE-->Desmethyl-5'-methoxylaudanosine-->Tetrahydropapaverine hydrochloride-->(R)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline-->TETRABENAZINE-->6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride-->[2-(3,4-DIMETHOXY-PHENYL)-ETHYL]-(5-METHYL-FURAN-2-YLMETHYL)-AMINE-->N-(3,4-DIMETHOXYPHENETHYL)ACETAMIDE-->1-(3,4-DIMETHOXYPHENETHYL)-5-OXO-3-PYRROLIDINECARBOXYLIC ACID-->4-(6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-1-YL)-PHENOL-->Benzamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-2-hydroxy- |
| Hazard Information | Back Directory | [Chemical Properties]
3,4-Dimethoxyphenethylamine is clear yellowish oil
| [Uses]
3,4-Dimethoxyphenethylamine is a methylated metabolite of Dopamine (D533780); a potent inhibitor of brain mitochondrial respiration used in Parkinson’s disease studies.
| [Definition]
ChEBI: An aromatic ether that is the derivative of 2-phenylethylamine with methoxy substituents at the 3- and 4-positions. It is an alkaloid isolated from the Cactaceae family. | [Flammability and Explosibility]
Notclassified | [Purification Methods]
Purify the amine by fractionation through an efficient column in an inert atmosphere as it is a relatively strong base. [Horner & Sturm Justus Liebigs Ann Chem 608 12819 1957, Jung et al. J Am Chem Soc 75 4664 1953.] The hydrochloride has m 152o, 154o, 156o (from EtOH, Me2CO or EtOH/Et2O), the picrate has m 165-167o(dec), and the 4-nitrobenzoyl derivative has m 147o [Buck J Am Chem Soc 55 2593 1933]. [Beilstein 13 H 800, 13 IV 2604.] |
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