| Identification | Back Directory | [Name]
CP 809101 hydrochloride | [CAS]
1215721-40-6 | [Synonyms]
CP-809101 HCl
CP809101 HYDROCHLORIDE;CP 809101 HYDROCHLORIDE
2-[(3-Chlorophenyl)methoxy]-6-(1-piperazinyl)pyrazine hydrochloride (1:1) | [Molecular Formula]
C15H18Cl2N4O | [MDL Number]
MFCD10687106 | [MOL File]
1215721-40-6.mol | [Molecular Weight]
341.236 |
| Hazard Information | Back Directory | [Uses]
CP-809101 hydrochloride is a potent and highly selective 5-HT2C receptor agonist, with pEC50s of 9.96, 7.19 and 6.81 M for human 5HT2C, 5HT2B and 5HT2A receptor. CP-809101 hydrochloride inhibits conditioned avoidance responding in rats and antagonizes both PCP (phencyclidine hydrochloride)- and d-amphetamine-induced hyperactivity. CP-809101 hydrochloride also reduces food and nicotine dependence in rats, can be used in studies of antipsychotic and nicotine dependence[1][2]. | [in vivo]
CP-809101 hydrochloride (0.1-56 mg/kg; s.c.; single) inhibits the conditioned avoidance response of rats in a dose-dependent manner[1].
CP-809101 hydrochloride (0.56, 1.78, 5.6, 17.8 mg/kg; s.c.; single) antagonizes PCP (phencyclidine hydrochloride)-induced and d-amphetamine-induced hyperactivity (the latter in a dose-dependent manner)[1].
CP-809101 hydrochloride (0.56, 1.78, 5.6, 17.8 mg/kg; s.c.; single) dose-dependently decreases spontaneous locomotor activity with an ED50 value of 2.2 mg/kg[1].
CP-809101 hydrochloride (0.3, 1, 3 mg/kg; s.c.; single) reduces responding for both nicotine and food and blocked the discriminative stimulus properties of nicotine[2]. | Animal Model: | Male CF rats (conditioned avoidance responding (CAR) model)[1]. | | Dosage: | 0.1-56 mg/kg | | Administration: | Subcutaneous injection; single. | | Result: | Resulted in a dose-dependent inhibition of the conditioned avoidance response with an ID50 value of 4.8 mg/kg. |
| Animal Model: | Male CD rats (PCP or d-amphetamine-induced hyperactivity model)[1]. | | Dosage: | 0.56, 1.78, 5.6, 17.8 mg/kg | | Administration: | Subcutaneous injection; single. | | Result: | Antagonized PCP-induced hyperactivity, with an ED50 value of 2.4 mg/kg.
Antagonized d-amphetamine-induced hyperactivity, with an ED50 value of 2.7 mg/kg, and in a dose-dependent manner.
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| Animal Model: | Male CD rats (spontaneous locomotor model)[1]. | | Dosage: | 0.56, 1.78, 5.6, 17.8 mg/kg | | Administration: | Subcutaneous injection; single. | | Result: | Inhibited spontaneous locomotor activity in a dose-dependent manner (ED50=2.7 mg/kg). |
| Animal Model: | Adult male Sprague-Dawley rats (280-400 g)[2]. | | Dosage: | 0.3, 1, 3 mg/kg | | Administration: | Subcutaneous injection; single. | | Result: | Produced a dose-related decrease in responding for food and nicotine self-administration in rats. |
| [IC 50]
5-HT2C Receptor: 9.96 (pEC50); 5-HT2B Receptor: 7.19 (pEC50); 5-HT2A Receptor: 6.81 (pEC50) | [storage]
Store at -20°C | [References]
[1] Siuciak JA, et al. CP-809,101, a selective 5-HT2C agonist, shows activity in animal models of antipsychotic activity. Neuropharmacology. 2007 Feb;52(2):279-90. DOI:10.1016/j.neuropharm.2006.07.024
[2] Higgins GA, et al. Evaluation of chemically diverse 5-HT?c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles. Psychopharmacology (Berl). 2013 Apr;226(3):475-90. DOI:10.1007/s00213-012-2919-2 |
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| Company Name: |
SPIRO PHARMA
|
| Tel: |
|
| Website: |
www.spiropharma.com.cn |
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
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