| Identification | Back Directory | [Name]
prepro-thyrotropin releasing hormone (160-169) | [CAS]
122018-91-1 | [Synonyms]
L-Threonine, L-seryl-L-phenylalanyl-L-prolyl-L-tryptophyl-L-methionyl-L-α-glutamyl-L-seryl-L-α-aspartyl-L-valyl- | [Molecular Formula]
C54H75N11O18S | [MOL File]
122018-91-1.mol | [Molecular Weight]
1198.31 |
| Hazard Information | Back Directory | [Uses]
Prepro-TRH-(160-169) is one of the connecting peptides of thyrotropin-releasing hormone prohormone (pro-TRH), potentiates TRH-induced thyrotropin (TSH) release[1]. | [in vivo]
In urethane-anesthetized rats, Prepro-TRH-(160-169) (Ps4; 100 ng, 150 ng and 200 ng; injected into dorsal motor nucleus (DMN)) potentiates TRH in the DMN-evoked gastric acid secretion through an action that is peptide and site specific[1]. | [References]
[1] H Yang, et al. Prepro-TRH-(160-169) potentiates gastric acid secretion stimulated by TRH microinjected into the dorsal motor nucleus of the vagus. Neurosci Lett. 1994 Jun 6;174(1):43-6. DOI:10.1016/0304-3940(94)90114-7
[2] J P Roussel, et al. Somatostatin blocks the potentiation of TRH-induced TSH secretion from perifused pituitary fragments and the change in intracellular calcium concentrations from dispersed pituitary cells elicited by prepro-TRH (PS4) or by tri-iodothyronine. J Mol Endocrinol. 1997 Aug;19(1):87-97. DOI:10.1677/jme.0.0190087 |
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