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73644-58-3

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73644-58-3 Structure

73644-58-3 Structure
IdentificationBack Directory
[Name]

PYR-HIS-PRO-BETANA
[CAS]

73644-58-3
[Synonyms]

TRH-bNA
TRH-βNA
TRH-BETANA
Pyr-His-Pro-bNA
PYR-HIS-PRO-BETANA
PYROGLU-HIS-PRO-BETA-NAPHTHYLAMIDE
THYROTROPIN-RELEASING HORMONE-BETANA
pyroglutamyl-histidyl-prolyl-2-naphthylamide
5-Oxo-L-prolyl-L-histidyl-N-2-naphthalenyl-L-prolinamide
L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-N-2-naphthalenyl-
[Molecular Formula]

C26H28N6O4
[MDL Number]

MFCD00038775
[MOL File]

73644-58-3.mol
[Molecular Weight]

488.54
Chemical PropertiesBack Directory
[storage temp. ]

-15°C
Safety DataBack Directory
[Symbol(GHS) ]

GHS hazard pictograms
GHS08
[Signal word ]

Danger
[Hazard statements ]

H350
Hazard InformationBack Directory
[Uses]

TRH-βNA is a substrate for determining the membrane TRH-deamidating enzyme (TRH-DE) activity and membrane pyroglutamyl aminopeptidase II (PPII) activity[1][2].
[References]

[1] Müller-Fielitz H, et al. Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis. Nat Commun. 2017 Sep 7;8(1):484. DOI:10.1038/s41467-017-00604-6
[2] Alvarez-Salas E, et al. Food-restricted and dehydrated-induced anorexic rats present differential TRH expression in anterior and caudal PVN. Role of type 2 deiodinase and pyroglutamyl aminopeptidase II. Endocrinology. 2012 Aug;153(8):4067-76. DOI:10.1210/en.2011-2011
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