| Identification | Back Directory | [Name]
TRH-GLY | [CAS]
85344-77-0 | [Synonyms]
TRH-GLY
PE-H-P-G
PYR-HIS-PRO-GLY
GLP-HIS-PRO-GLY
pglu-his-pro-gly
PYR-HIS-PRO-GLY-OH
GLP-HIS-PRO-GLY: GLP-HPG
TRH-Gly Pyr-His-Pro-Gly-OH
THYROTROPIN-RELEASING HORMONE-GLY
Glycine, 5-oxo-L-prolyl-L-histidyl-L-prolyl- | [Molecular Formula]
C18H24N6O6 | [MDL Number]
MFCD00167621 | [MOL File]
85344-77-0.mol | [Molecular Weight]
420.42 |
| Hazard Information | Back Directory | [Uses]
Trh-gly (TRH-glycine) is a precursor of thyrotropin (TSH)-releasing hormone (TRH) that can release thyrotropin and prolactin[1]. | [in vivo]
In urethane-anesthetized 2-month-old (250 g) male Sprague-Dawley rats, Trh-gly (intracisternal injection; 1.0 mg) leads to a significant increase in the TRH levels in hypothalamus, medulla and blood[1]. | [References]
[1] A E Pekary, et al. Release of thyrotropin and prolactin by a thyrotropin-releasing hormone (TRH) precursor, TRH-Gly: conversion to TRH is sufficient for in vivo effects. Neuroendocrinology. 1990 Dec;52(6):618-25. DOI:10.1159/000125654
[2] M Yamada, et al. Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly. Neurosci Lett. 1995 Aug 18;196(1-2):109-12. DOI:10.1016/0304-3940(95)11861-p |
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