| Identification | More | [Name]
N-(3-Aminopropyl)morpholine | [CAS]
123-00-2 | [Synonyms]
3-(1-MORPHOLINO)-1-PROPYLAMINE
3-(4-MORPHOLINO)-1-PROPYLAMINE
3-MORPHOLIN-4-YLPROPAN-1-AMINE
3-MORPHOLIN-4-YL-PROPYLAMINE
3-MORPHOLINO-1-PROPYLAMINE
3-MORPHOLINOPROPYLAMINE
4-(3-AMINOPROPYL)MORPHOLINE
4-Aminopropyl morpholine
4-MORPHOLINEPROPANAMINE
AKOS MSC-0738
AMP
LABOTEST-BB LT00731422
N-(3-AMINOPROPYL)MORPHOLINE
N-AMINOPROPYL-MORPHLINE
N-AMINOPROPYLMORPHOLINE
NAPM
RARECHEM AL BW 1351
(3-Aminopropyl)morpholine
1-Amino-3-morpholinopropane
3-(4-Morpholinyl)-1-propanamine | [EINECS(EC#)]
204-590-2 | [Molecular Formula]
C7H16N2O | [MDL Number]
MFCD00006184 | [Molecular Weight]
144.21 | [MOL File]
123-00-2.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear liquid | [Melting point ]
−15 °C(lit.) | [Boiling point ]
224 °C(lit.) | [density ]
0.987 g/mL at 25 °C(lit.)
| [vapor density ]
4.97 | [vapor pressure ]
11.5Pa at 20℃ | [refractive index ]
n20/D 1.4761(lit.)
| [Fp ]
210 °F
| [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
1000g/l | [form ]
Liquid | [pka]
10.30±0.10(Predicted) | [color ]
Colorless to Almost colorless | [PH]
12 (H2O, 20℃) | [Water Solubility ]
Soluble | [Sensitive ]
Air Sensitive | [Detection Methods]
GC,NMR | [BRN ]
105104 | [InChI]
1S/C7H16N2O/c8-2-1-3-9-4-6-10-7-5-9/h1-8H2 | [InChIKey]
UIKUBYKUYUSRSM-UHFFFAOYSA-N | [SMILES]
NCCCN1CCOCC1 | [LogP]
-1.076 at 20℃ and pH10.81-11.03 | [Surface tension]
70.3mN/m at 1g/L and 20℃ | [Dissociation constant]
10.08 | [CAS DataBase Reference]
123-00-2(CAS DataBase Reference) | [NIST Chemistry Reference]
4-Morpholinepropanamine(123-00-2) | [EPA Substance Registry System]
123-00-2(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
 
GHS05,GHS07 | [Signal word ]
Danger | [Hazard statements ]
H302-H314 | [Precautionary statements ]
P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P305+P351+P338+P310 | [Hazard Codes ]
C,Xi | [Risk Statements ]
R21:Harmful in contact with skin.
R34:Causes burns.
R21/22:Harmful in contact with skin and if swallowed .
R36/37:Irritating to eyes and respiratory system . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 2735 8/PG 2
| [WGK Germany ]
2
| [RTECS ]
QD7700000
| [F ]
10-34 | [TSCA ]
Yes | [REACH Registrations]
Active | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29349990 | [Storage Class]
8A - Combustible corrosive hazardous materials | [Hazard Classifications]
Acute Tox. 4 Oral
Eye Dam. 1
Skin Corr. 1B | [Safety Profile]
A corrosive material. Moderately toxic by several routes. A severe skin and eye irritant. Combustible. Can react with oxidizing materials. To fight fire, use alcohol foam, dry chemical. When heated to decomposition it emits toxic fumes of NOx,. | [Toxicity]
LD50 orl-rat: 3560 mg/kg UCDS** 3/25/70 |
| Hazard Information | Back Directory | [General Description]
A colorless liquid with a faint, fishlike odor. Burns, but requires some effort to ignite. Corrosive to tissue. Produces toxic oxides of nitrogen during combustion. | [Reactivity Profile]
N-AMINOPROPYLMORPHOLINE(123-00-2) behaves as an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. | [Air & Water Reactions]
Soluble in water. | [Health Hazard]
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution. | [Fire Hazard]
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated. | [Chemical Properties]
Clear liquid | [Uses]
3-(4-Morpholinyl)propylamine is catalytic agent, petrochemical additive. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. | [Uses]
Fiber synthesis; chemical intermediate. | [Definition]
ChEBI: A member of the class of morpholines that is morpholine substituted by a 3-aminopropyl group a the N atom. | [Hazard]
Strongly irritant to tissue. | [Synthesis]
The general procedure for the synthesis of morpholine and 3-(4-morpholinyl)-1-propanamine from 3-(4-morpholinyl)propanenitrile was as follows: sodium borohydride (0.6 g, 0.016 mol), 15 mL of tert-butanol, anhydrous nickel(II) chloride (1.0 g, 0.008 mol), and 3-(4-morpholinyl)propanenitrile (14 g, 0.1 mol) were added to the reaction system. The reaction was carried out at 70 °C for 8 hours. Upon completion of the reaction, morpholine (product 1) was obtained in 22 wt%. The results of mass spectral analysis were as follows: m/e (relative intensity, %): 88.8 (2) [M + 2], 87.9 (59) [M + 1], 86.8 (67) [M], 86.0 (100), 56.9 (86), 55.9 (98), 41.9 (28). Also, 3-N-morpholino-1-aminopropane (product 2) was obtained at 59 wt%. The results of mass spectrometry analysis were as follows: m/e (relative intensity, %): 145.0 (5) [M + 1], 128.0 (1.5), 126.8 (7), 113.0 (32), 101.0 (11), 100.0 (100), 86.0 (7), 72.0 (10), 70.0 (30), 57.0 (11), 56.0 (35 ), 42.0 (30). | [References]
[1] Russian Journal of General Chemistry, 2016, vol. 86, # 2, p. 273 - 280
[2] Zh. Obshch. Khim., 2016, vol. 86, # 2, p. 245 - 252,8 |
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