| Identification | More | [Name]
Propylamine | [CAS]
107-10-8 | [Synonyms]
1-AMINOPROPANE
1-PROPANAMINE
AMINE C3
AURORA KA-690
MNPA
MONO-N-PROPYLAMINE
N-PROPYLAMINE
PA
PROPANEAMINE
PROPYLAMINE
RARECHEM AL BW 0067
1-Aminopropan
1-Amino-propan
1-Propylamine
Monopropylamine
n-C3H7NH2
Propanamine
Propylamin
propylamine(normale)
propylamine2,4-dichlorophenoxyacetate | [EINECS(EC#)]
203-462-3 | [Molecular Formula]
C3H9N | [MDL Number]
MFCD00008205 | [Molecular Weight]
59.11 | [MOL File]
107-10-8.mol |
| Chemical Properties | Back Directory | [Appearance]
n-Propylamine is a water-white liquid with a
strong irritating odor similar to that of ammonia | [Melting point ]
-83 °C (lit.) | [Boiling point ]
48 °C (lit.) | [density ]
0.719 g/mL at 25 °C(lit.)
| [vapor density ]
2 (vs air)
| [vapor pressure ]
4.79 psi ( 20 °C)
| [FEMA ]
4237 | [refractive index ]
n20/D 1.388(lit.)
| [Fp ]
−35 °F
| [storage temp. ]
0-6°C
| [solubility ]
water: soluble0.4 part(lit.) | [form ]
Liquid | [pka]
10.6(at 20℃) | [color ]
Clear colorless to pale yellow | [Specific Gravity]
0.7173 | [Odor]
ammoniacal | [PH]
12.6 (100g/l, H2O, 20℃) | [Stability:]
Stable. Highly flammable. Note low flash point. Readily forms explosive mixtures with air. Incompatible with oxidising agents, strong acids. Store cool. | [explosive limit]
2.1-13.6%(V) | [Odor Threshold]
0.061ppm | [Odor Type]
ammoniacal | [Water Solubility ]
soluble | [Sensitive ]
Air Sensitive | [JECFA Number]
1580 | [Merck ]
14,7843 | [BRN ]
1098243 | [Dielectric constant]
3.0（Ambient） | [Exposure limits]
No exposure limit has been set. Based on its
similarity to ethylamine in irritation and toxicity, a TLV-TWA of 10 ppm (～24 mg/m3)
should be appropriate.
. | [LogP]
0.55 | [Uses]
Intermediate, lab reagent.
| [CAS DataBase Reference]
107-10-8(CAS DataBase Reference) | [NIST Chemistry Reference]
1-Propanamine(107-10-8) | [EPA Substance Registry System]
107-10-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
F,C | [Risk Statements ]
R11:Highly Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S16:Keep away from sources of ignition-No smoking .
S7/9:Keep container tightly closed and in a well-ventilated place .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 1277 3/PG 2
| [WGK Germany ]
1
| [RTECS ]
UH9100000
| [F ]
34 | [Autoignition Temperature]
604 °F | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29211990 | [Safety Profile]
Moderately toxic by
inhalation, ingestion, and skin contact
routes. A skin and severe eye irritant.
Possibly a skin sensitizer. Very dangerous
fire hazard when exposed to heat, flame, or
oxidizers. Explosive in the form of vapor
when exposed to heat or flame. To fight
fire, use alcohol foam. When heated to
decomposition it emits toxic fumes of NOx.
Incompatible with triethynyl aluminum. See
also AMINES. | [Hazardous Substances Data]
107-10-8(Hazardous Substances Data) | [Toxicity]
LD50 orally in rats: 0.57 g/kg (Smyth) |
| Hazard Information | Back Directory | [General Description]
Propylamine(107-10-8) appears as a clear colorless liquid with an ammonia-like odor. Flash point -35 °F. Less dense than water and soluble in water. Vapors are heavier than air. Produces toxic oxides of nitrogen during combustion. Used in chemical analysis and to make other chemicals.
| [Reactivity Profile]
Colorless, alkaline liquid, very volatile (b. p. 48° C), moderately toxic, highly flammable. Dangerous fire hazard when exposed to heat, flame, sparks, or strong oxidizers. When heated to decomposition MONOPROPYLAMINE(107-10-8) emits toxic fumes of oxides of nitrogen. Incompatible with triethylaluminum, complex may explode on sublimation [Chini, P. et al., Chim. e Ind (Milan), 1962, 44, p. 1220]. | [Air & Water Reactions]
Highly flammable. Slightly soluble in water. | [Hazard]
Highly flammable, dangerous fire risk,
explosive limits in air 2–10%, use alcohol foam
to extinguish. Strong irritant to skin and tissue.
| [Health Hazard]
INHALATION: Mucous membrane and respiratory tract irritation. Tracheitis, bronchitis, pneumonitis, and pulmonary edema. EYES: Severe corneal damage or complete eye destruction. SKIN: Single drop-deep necrosis. INGESTION: Corrosive to G.I. tract. | [Potential Exposure]
Propylamine is used to make textile
resins, drugs, pesticides, and other chemicals. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, includ-
ing resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medi-
cal attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit.
Medical observation is recommended for 24?48 hours after
breathing overexposure, as pulmonary edema may be
delayed. As first aid for pulmonary edema, a doctor or
authorized paramedic may consider administering a drug or
other inhalation therapy. | [Shipping]
UN1277 Propylamine, Hazard Class: 3; Labels:
3-Flammable liquid, 8-Corrosive material. | [Incompatibilities]
Vapors may form explosive mixture with
air. Violent reaction on contact with oxidizers and mercury,
strong acids; organic anhydrides; isocyanates, aldehydes,
nitroparrafins, halogenated hydrocarbons; alcohols and
many other compounds. Attacks many metals and alloys,
especially those of copper. Aqueous solution is acidic and
may attack glass. | [Description]
Propylamine, with the chemical formula C3H9N, is a colorless and volatile liquid. It can be dissolved in various solvents such as water, ethanol, ether, acetone, benzene, and other organic solvents. Its specific gravity is 0.7, making it lighter than water. Propylamine has a flammable range of 2% to 10% in air and is flammable. It has a boiling point of 120°F (48°C), flash point of 35°F (37°C), and an ignition temperature of 604°F (317°C). Its vapor density is 2, heavier than air, and can form explosive mixtures when combined with air. It can burn and is corrosive, causing skin and tissue irritation. Its primary uses are as a chemical intermediate and a lab reagent. | [Chemical Properties]
n-Propylamine, also known as propylamine or 107-10-8, is a colorless liquid with a pungent odor resembling ammonia. It has strong basic properties, leading to its easy formation of salts when combined with acids. Its reactivity is similar to that described for the other short chain aliphatic amines (Astel 1961). | [Waste Disposal]
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations
governing storage, transportation, treatment, and waste
disposal. | [Definition]
ChEBI: Propylamine is a member of the class of alkylamines that is propane substituted by an amino group at C-1. It is a conjugate base of a propan-1-aminium. | [Production Methods]
There are several methods employed in the manufacture of propylamine. Typically,
ammonia and propanol are reacted over a dehydration catalyst at high temperature
and pressure. Ammonia, propanol, and hydrogen can also be reacted over a
dehydrogenation catalyst such as metallic silver. Propylamine can also be synthesized
from propionaldehyde and ammonia with a Raney nickel catalyst (Schweizer
et al 1978). | [Aroma threshold values]
High strength odor; ammoniacal type; recommend smelling in a 0.10% solution or less. | [Fire Hazard]
Highly flammable liquid; flash point (closed
cup) -37°C (-35°F); vapor density 2.0
(air = 1), vapor can travel a considerable distance to a source of ignition and flash back;
autoignition temperature 318°C (604°F); fire extinguishing agent: dry chemical, CO2, or
“alcohol” foam; water should be used to keep
fire-exposed containers cool and to flush and
dilute the spill.
n-Propylamine forms explosive mixtures
in air; LEL and UEL values are 2.0% and
10.4% by volume in air, respectively. There
is no report of explosion associated with this
compound. It is expected to exhibit violent
reactions characteristic of lower aliphatic
primary amines . | [Industrial uses]
Propylamine is important as a chemical intermediate for rubber chemicals, dyestuffs,
propyl isocyanate, textile and leather finishing resins and corrosion inhibitors.
It is also used in the production of pharmaceuticals such as Prilocaine,
pesticides including Profluralin and in petroleum additives. In 1976, 500 tons of
propylamine were manufactured in the U.S. (HSDB 1988). | [Metabolism]
To date, there are several studies which indicate that propylamine may be
metabolized in many animal species, including man. When propylamine hydrochloride
was administered to humans orally, little of the parent compound was
recovered in the urine (Rechenberger 1940). It has also been reported that dogs are
capable of metabolizing propylamine (Bernhard 1938). McEwen et al (1966)
demonstrated that monoamine oxidase, purified from rabbit serum, was capable of
oxidizing propylamine, although less actively than substituted phenylethylamines
such as dopamine. Further characterization revealed that the protonated amine is
bound by an unprotonated enzyme group, that the enzyme active site is composed
of hydrophobic residues, and that interaction of the amine residues determines
maximal velocity and affinity constant (McEwen and Sober 1967). Oxidation of
the amine could be stimulated by the presence of aliphatic alcohols which
apparently bond in a tertiary complex with the enzyme and substrate, thereby
increasing the effectiveness of substrate binding.
Other investigators have provided evidence that propylamine may not be a
substrate for tissue monoamine oxidase. When given intraperitoneally to rats it had
no effect on the liver enzyme and little effect on activity in the brain (Valiev 1974).
Early work by Pugh and Quastel (1937) indicated that slices of rat brain did not
metabolize propylamine. | [Purification Methods]
Distil the amine from zinc dust, under reduced pressure, in an atmosphere of nitrogen. [Beilstein 4 IV 464.] |
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