| Identification | Back Directory | [Name]
CGP 35348 | [CAS]
123690-79-9 | [Synonyms]
CGP 35348
CGP 35348 hydrate
(3-AMINOPROPYL)(DIETHOXYMETHYL)PHOSPHINIC ACID
Phosphinic acid, (3-aminopropyl)(diethoxymethyl)-
P-(3-Aminopropyl)-P-(diethoxymethyl)phosphinic acid
(3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate | [Molecular Formula]
C8H20NO4P | [MDL Number]
MFCD00882736 | [MOL File]
123690-79-9.mol | [Molecular Weight]
225.22 |
| Chemical Properties | Back Directory | [storage temp. ]
−20°C | [solubility ]
H2O: >10 mg/mL | [form ]
solid | [color ]
white | [Water Solubility ]
Soluble in water (100mM) | [InChI]
1S/C8H20NO4P.H2O/c1-3-12-8(13-4-2)14(10,11)7-5-6-9;/h8H,3-7,9H2,1-2H3,(H,10,11);1H2 | [InChIKey]
SRBHGEXMDCJOMS-UHFFFAOYSA-N | [SMILES]
O.CCOC(OCC)P(O)(=O)CCCN |
| Hazard Information | Back Directory | [Uses]
CGP 35348 hydrate has been used as a γ-aminobutyric acid-B (GABAB) receptor inhibitor:
- to study its effects on intrinsic optical signal (IOS) in rat hippocampus
- alone or in combination with sodium salicylate to study its effects on auditory responses in the rat′s dorsal cortex of rat
- to study its effects on hepatocellular carcinoma cells (HCC)
| [Biological Activity]
Selective, brain penetrant GABA B receptor antagonist (IC 50 = 34 μ M as measured in rat cortical membranes). Has higher affinity for postsynaptic versus presynaptic receptors. | [Biochem/physiol Actions]
CGP 35348 is a γ-aminobutyric acid-B (GABAB) receptor antagonist. It has a higher affinity towards post-versus presynaptic receptors that can penetrate the blood-brain barrier. | [storage]
Room temperature | [References]
[1]. olpe hr, karlsson g, pozza mf, et al. cgp 35348: a centrally active blocker of gabab receptors. eur j pharmacol, 1990, 187(1): 27-38.
[2]. hammond dl, washington jd. antagonism of l-baclofen-induced antinociception by cgp 35348 in the spinal cord of the rat. eur j pharmacol, 1993, 234(2-3): 255-262.
[3]. hao jx, xu xj, wiesenfeld-hallin z. intrathecal gamma-aminobutyric acidb (gabab) receptor antagonist cgp 35348 induces hypersensitivity to mechanical stimuli in the rat. neurosci lett, 1994, 182(2): 299-302.
[4]. patel sm, ebenezer is. the effects of intraperitoneal and intracerebroventricular administration of the gabab receptor antagonist cgp 35348 on food intake in rats. eur j pharmacol, 2004, 503(1-3): 89-93. |
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Sigma-Aldrich
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BOC Sciences
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Energy Chemical
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http://www.energy-chemical.com |
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