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9004-65-3

9004-65-3 Structure

9004-65-3 Structure
IdentificationBack Directory
[Name]

Hydroxypropyl methyl cellulose
[CAS]

9004-65-3
[Synonyms]

HPMC
MHPC
hpmcd
goniosol
HPMC/MHPC
HPMC /HEMC
methocelhg
isoptoplain
isoptotears
METHOCEL E4M
HYPROMELLOSE
METHOCEL K100
methocele,f,k
isoptoalkaline
HYPOMELLOSE 2208
HYPOMELLOSE 2906
HYPOMELLOSE 2910
HYPROMELLOSE, 2208
HYPROMELLOSE, 2910
MODIFIED CELLULOSE
Hydroxypropyl methyl
HYDROXYPROPYL METOLOSE
METHOCEL(TM) F PREMIUM
METHOCEL(TM) K4 PREMIUM
METHOCEL(TM) E3 PREMIUM
Hydroxyproxyl Cellulose
HYPROMELLOSE,2910,50CPS,USP
Hydroxypropyl methylcellose
HYDROXPROPYLMETHYLCELLULOSE
Hydroxymethylpropylcellulose
METHYLHYDROXYPROPYLCELLULOSE
HYPROMELLOSE,2208,100CPS,USP
hydroxylpropylmethylcellulose
HYPROMELLOSE,2208,4,000CPS,USP
PROPYLENEGLYCOLMETHYLCELLULOSE
(HYDROXYPROPYL)METHYL CELLULOSE
HYDROXYPROPYLMETHYLCELLULOSEGEL
hydroxypropypyl methyl cellulose
HYDROXYPROPYL MODIFIED CELLULOSE
HYPROMELLOSE,2208,100,000CPS,USP
viscosity 4,000 cP (2% solution)
HYDROXYPROPYLMETHYLCELLULOSE 2910
HYDROXYPROPYL METHYLCELLULOSE 2208
HydroxypropylMethylCellulose(Hpmc)
Hydroxypropyl Methyl cellulose USP
(HYDROXYPROPYL)METHYL CELLULOSE, 15
HYDROXYPROPYLMETHYLCELLULOSE 2910, U
HYDROXYPROPYLMETHYLCELLULOSE APPROX*
Cellulose,2-hydroxymethylpropylether
cellulose,2-hydroxypropylmethylether
HydroxyPropylMethylCelluloseHpmcE15Lv
HydroxyPropylMethylCelluloseHpmcE50Lv
HYDROXYPROPYLMETHYLCELLULOSE,50CPS,FCC
HYDROXYPROPYLMETHYLCELLULOSE 2910, USP
viscosity 4,000 cP (2% solution) 100GR
HYDROXYPROPYLMETHYLCELLULOSE,100CPS,FCC
Methylcellulose, propylene glycol ether
Hydroxy Propyl Methyl Cellulose/HPMC E50
High-Substituted Hydroxyproxyl Cellulose
Hydroxy Propyl Methyl Cellulose/HPMC K15M
HYDROXYPROPYLMETHYLCELLULOSE,4,000CPS,FCC
PROPYLENE GLYCOL ETHER OF METHYLCELLULOSE
Hydroxypropyl Methyl Cellulose (Mpmc), Cas
(HYDROXYPROPYL)METHYL CELLULOSE, 15 MPA. S
(HYDROXYPROPYL)METHYLCELLULOSE, 30-65 MPA.S
(HYDROXYPROPYL)METHYL CELLULOSE,1500 MPA .S
HydroxyPropylMethylCelluloseHpmcE5LvPremium
Hydroxypropyl methyl cellulose, M.N. 86,000
(HYDROXYPROPYL)METHYL CELLULOSE,15000 MP A.S
(HYDROXYPROPYL)METHYL CELLULOSE, ~4000 M PA.S
(HYDROXYPROPYL)METHYL CELLULOSE,100000 M PA.S
HYDROXYPROPYL METHYL CELLULOSE (HPMC) (13.0-18.0 M
HYDROXYPROPYL METHYL CELLULOSE (HPMC) (3.0-7.0 MPA
HYDROXYPROPYL METHYL CELLULOSE (HPMC) (40.0-60.0 M
HYDROXYPROPYL METHYL CELLULOSE (HPMC) (8.0-12.0 MP
(Hydroxypropyl)Methyl cellulose average Mn ~10,000
(Hydroxypropyl)Methyl cellulose average Mn ~86,000
(Hydroxypropyl)methyl cellulose average Mn ~90,000
(Hydroxypropyl)methyl cellulose average Mn ~120,000
HyproMellose, Substitution Type 2910, 50 MPa.s, USP
HYDROXYPROPYLMETHYLCELLULOSE APPROX*50 C ENTIPOISES
HYDROXYPROPYLMETHYLCELLULOSE*ELECTROPHOR ESIS REAGEN
HYDROXYPROPYLMETHYLCELLULOSE APPROX*4,00 0 CENTIPOIS
HYDROXYPROPYLMETHYLCELLULOSE APPROX.*100 CENTIPOISE
HyproMellose, Substitution Type 2208, 100 MPa.s, USP
Hypromellose (250 mg) (Hydroxypropyl Methylcellulose)
HyproMellose, Substitution Type 2910, 4000 MPa.s, USP
HyproMellose, Substitution Type 2208, 4,000 MPa.s, USP
HyproMellose, Substitution Type 2208, 100,000 MPa.s, USP
HYDROXYPROPYL METHYL CELLULOSE (VISC. 2% AQ. SOLN. = 6CPS)
HYDROXYPROPYL METHYL CELLULOSE (VISC. 2% AQ. SOLN. = 50CPS)
HYDROXYPROPYL METHYL CELLULOSE (VISC. 2% AQ. SOLN. = 4,000CPS)
HYDROXYPROPYL METHYL CELLULOSE (VISC. 2% AQ. SOLN. = 80-120CPS)
HYDROXYPROPYL METHYL CELLULOSE (VISC. 2% AQ. SOLN. = 15,000CPS)
HYDROXYPROPYL METHYL CELLULOSE (VISC. 2% AQ. SOLN. = 100,000CPS)
(Hydroxypropyl)methyl cellulose, Hydroxypropylmethylcellulose 2910
Hydroxypropyl methyl cellulose, m.n. 86,000: viscosity 4,000 cp (2% solution)
Hydroxypropyl Methylcellulose, 28-30% Methoxyl, 7-12% hydroxypropyl, viscosity (2% aq. soln., 20°C) 7500-14000 MPa.s
[EINECS(EC#)]

220-971-6
[Molecular Formula]

C3H7O *
[MDL Number]

MFCD00131360
[MOL File]

9004-65-3.mol
[Molecular Weight]

59.0871
Chemical PropertiesBack Directory
[Appearance]

white or slightly beige powder or a viscous solution
[density ]

1.39
[solubility ]

H2O: 50 mg/mL, clear to very faintly turbid, faintly yellow
[form ]

powder
[Stability:]

Stable. Solid is combustible, incompatible with strong oxidizing agents.
[Water Solubility ]

SOLUBLE
[Merck ]

14,4842
[Uses]

Hydroxypropyl Methylcellulose is a gum formed by the reaction of propylene oxide and methyl chloride with alkali cellulose. it will gel as the temperature is increased in heating and upon cooling will liquefy. the gel temperature ranges from 60°c to 90°c, forming semifirm to mushy gels. it is used in bakery goods, dressings, breaded foods, and salad dressing mix for syneresis control, texture, and to provide hot viscosity. usage level ranges from 0.05 to 1.0%.
[EPA Substance Registry System]

Cellulose, 2-hydroxypropyl methyl ether(9004-65-3)
Hazard InformationBack Directory
[Chemical Properties]

white or slightly beige powder or a viscous solution
Safety DataBack Directory
[Safety Statements ]

24/25
[WGK Germany ]

1
[RTECS ]

NF9125000
[F ]

3-10
[TSCA ]

Yes
[HS Code ]

39129000
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Sodium hydroxide-->Hydrochloric acid-->Methanol-->ETHYLENE OXIDE-->Propylene oxide-->METHYL CHLORIDE-->Cellulose microcrystalline-->Defatted cotton-->Cotton brei pulp-->GOSSYPIN
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Hydroxypropyl methyl cellulose(9004-65-3).msds
Questions And AnswerBack Directory
[Product features]

Hydroxypropyl methyl cellulose is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.It is white or pale white cellulose powder or particles. The characteristics of cold water dissolution and hot water insoluble are similar with methyl cellulose. Solubility in organic solvents is superior than water soluble, can be dissolved in anhydrous methanol and ethanol solution, also soluble in chlorinated hydrocarbons and ketones in organic solvents. Soluble in water, its water solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the reversible conversion of sol to gel. Can be used alone in the cold drink, also can be used with other emulsifier, stabilizer. To cold drink, the maximum amount is 1%. Hydroxypropyl methyl cellulose and other water-soluble high weight compounds use mixture, become transparent, higher viscosity. The gelation temperature of low viscosity products is higher than high viscosity of products. Its solution is stable at room temperature. In recent years, It has been widely used in petroleum chemical industry, papermaking, leather, textile printing and dyeing, pharmaceutical, food, cosmetics and other industries, and as the dispersing agent, thickening agent, adhesive, excipient, capsule, oil resistant coating and packing etc.
The molecular structure of hydroxypropyl methyl cellulose
Figure 1 The molecular structure of hydroxypropyl methyl cellulose
[Usage method]

Purpose: thickener, emulsifier, stabilizer.
1 note: hydroxypropyl methyl cellulose has many excellent properties. It can be used for baking food, pasty food, enriched food, milk paste mixing drinks, pie fillings, toppings, salad and fast food. The use of its thermal gel properties can make deep fried food, not only can save a lot of oil, but also the product has a unique taste of the soft. The use of its acid, alkali stability, anti-enzymes, do not participate in metabolism, enhance the characteristics of gastrointestinal motility, but also used to produce a variety of health food.
2 usage range and usage
(1) The provisions on the use of hygienic standards for food additives (GB 2760-1996) shall be used in all kinds of food appropriately.
(2) The actual use of reference: the use of high transparency film and film of this product can be used in the manufacture of casings, dosage is 5%. It is used as a thickener mayonnaise (HPMC-60RT400), dosage of 0.5%~2%.
[Ophthalmic remedy]

[Application] Through the stability and thickening of anterior corneal tear, it can promote corneal moist, cut off time, extend the tear film in dry eyes and can prolong the retention time of tear film. It used for the lack of clinical tear caused by dry eyes and eye irritation, and the treatment of keratoconjunctivitis sicca, exposure keratitis and Neuroparalytic keratitis to prevent corneal injury. It can be used for hard contact lenses or artificial eye lubricant. For gonioscopy, contact endoscopy and surgery, it is as a medium in condensation genioplasty or retinal laser iridectomy in the process to protect the cornea.
[dosage] eye: 0.3%~1% solution, 1 drops, 3~4 times /d. 2% of the solution is used for the anterior chamber angle.
[Attention and taboo] Using it can sometimes have blurred vision or eyelid adhesion feeling. Continuous time should not exceed 3 Days. Wearing soft contact lens is banned to corneal epithelial disease. Wear a hard contact lens should prevent the lens floating.
[Specification] eye drops: 0.3%, 0.5%, 1%, 2.5%.
This information is edited by Chemicalbook Xiannan (2015-08-31).
[Identification test]

It is soluble in water swelling, forming a transparent milky white sticky gel solution, and insoluble in ethanol.
[Toxicity]

ADI does not make special provisions (FAO/WHO, 2001). It can be used for food safety (FDA. §172.87, 2000). LD505200mg/kg (rats, intra peritoneal injection).
[Limited use]

FAO/WHO (1984): Cold drink ,10g/kg (in the end product design, single use or with other emulsifier, stabilizer and thickener dosage).
GB 2760-96: all kinds of food, to GMP limited.
[Chemical property]

Hydroxypropyl methyl cellulose is propylene glycol ether of methyl cellulose, hydroxypropyl and methyl combine with anhydrous glucose ring by ether bond.It is white or pale white cellulose powder or particles.It has different types of products, the methoxy and hydroxypropyl content ratio is different. It is white or gray fibrous powder or particles. It is soluble in water and some organic solvents and unsoluble in ethanol. Aqueous solution has a surface activity, the formation of the film after drying, heated and cooled, in turn, from the sol to gel reversible transformation.
[Uses]

1. Thickener, stabilizer, emulsifier, emulsifier, suspending agent.
2. It is used as a synthetic resin dispersing agent, and the coating agent,also used as a thickener.
3. This product is used as a thickener, dispersant, binder, emulsifier and stabilizer in the textile industry. It is also widely used in synthetic resin, petrochemical, ceramics, paper, leather, medicine, food, cosmetics and other industries.
4. Used in synthetic resin, petroleum chemical industry, ceramics, paper, leather, textile, medicine, food, cosmetics and other daily chemicals and as dispersing agent, thickening agent, binders, excipients, capsules, oil resistant coating and packing etc.
[Methods of production]

1.The refined cotton cellulose with alkali treatment at 35-40 ℃ for half an hour, press, crushed the cellulose, aging at 35 ℃, so that the average degree of polymerization of alkali cellulose is in a desired range. The alkali fiber into etherification reactor, followed by adding epoxy propane and methane chloride, etherification at 50-80 ℃ for 5h, the maximum pressure is about 1.8MPa. The reaction products were produced by postprocessing (hydrochloric acid and oxalic acid, washing and drying). The consumption of raw material of cotton pulp 1100kg/t, methyl chloride and propylene oxide 4300kg/t, solid alkali 1200kg/t, hydrochloride 30kg/t, oxalic acid 50kg/t.
2.100 kg refined cotton linters immersed in 45% solution, temperature is 35 to 40℃, time is 0.5 to 1 h, and then remove the press. The pressure to weight is 2.7 times as the weight of lint, stop pressure. Carry out the crushing. At 35℃, aging for 16h.
In the reaction kettle, the chlorinated methane, propylene oxide were added into the reaction kettle. At 80℃, the pressure was 1.8 MPa, the reaction time is 5 to 8 h, and the amount of hydrochloric acid and oxalic acid were added to the hot water at 90℃. Dewatering with centrifuge, washing to neutral, when the water content of the material is below to 60% , 130℃ of hot air flow dried to the moisture content is below 5%. Finally, the finished product sieved by 20 mesh.
3. Prepared by cellulose, methyl chloride, and ethylene oxide.
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