| Identification | Back Directory | [Name]
GNF-6231 | [CAS]
1243245-18-2 | [Synonyms]
GNF6231
GNF-6231
[2,4'-Bipyridine]-5-acetamide, N-[5-(4-acetyl-1-piperazinyl)-2-pyridinyl]-2'-fluoro-3-methyl- | [Molecular Formula]
C24H25FN6O2 | [MOL File]
1243245-18-2.mol | [Molecular Weight]
448.49 |
| Chemical Properties | Back Directory | [Melting point ]
>174°C (dec.) | [Boiling point ]
746.0±60.0 °C(Predicted) | [density ]
1.306±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C Freezer, Under inert atmosphere | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly, Heated, Sonicated) | [form ]
Solid | [pka]
12.60±0.70(Predicted) | [color ]
Pale Brown to Light Brown |
| Hazard Information | Back Directory | [Uses]
GNF-6231 was used in the study to prepare N-?(hetero)?aryl, 2-?(hetero)?aryl-?substituted acetamides for use as Wnt signaling modulators. Blockade of aberrant Wnt signaling is an attractive therapeutic approach in multiple cancers. | [in vivo]
GNF-6231 (5 mg/kg; Intravenous injection (i.v.); every 24 hours for 6 days) alleviates the symptoms of myocardial infarction in C57Bl/6 mice by inhibiting the activation of the Wnt pathway[1].
GNF-6231 (0.3-3 mg/kg; p.o.; once daily for 2 weeks) shows antitumor activity in a mouse of MMTV-WNT1 xenograft tumor[4].
| Animal Model: | C57Bl/6 mice model of myocardial infarction[1] | | Dosage: | 5 mg/kg | | Administration: | Intravenous injection (i.v.); Starting from 6 hours after myocardial infarction surgery to the sixth day after infarction, once every 24 hours | | Result: | Reduced nuclear and cytoplasmic β-catenin levels.
Reduced adverse cardiac remodeling and reduced myocardial infarction area in mice (9.07%).
Enhanced the overall heart repair and recovery after left ventricular infarction.
|
| Animal Model: | Mouse MMTV-WNT1 xenograft tumor model[2] | | Dosage: | 0.3 mg/kg,1.0 mg/kg, 3 mg/kg | | Administration: | Oral gavage; Once daily for 2 weeks | | Result: | At a single dose of 3 mg/kg, reduced the level of Wnt target gene Axin2 mRNA.
Promoted tumor regression in mice in a dose-dependent manner.
|
| [storage]
Store at -20°C |
|
| Company Name: |
Musechem
|
| Tel: |
+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
ChemeGen
|
| Tel: |
18818260767 |
| Website: |
https://www.chemegen.com |
|