| Identification | Back Directory | [Name]
N-DeMethyl Ivabradine Hydrochloride | [CAS]
1246638-08-3 | [Synonyms]
I-305
S 18982
Ivabradine Impurity b
Ivabradine Impurity 39
N-Desmethyl Ivabradine
Ivabradine N-Desmethyl HCl
N-Desmethyl Ivabradine HCl
N-Demethyl Ivabradine-d6 HCl
N-DeMethyl Ivabradine Hydrochloride
N-DesMethyl Ivabradine Hydrochloride
IVABRADINE N-desmethyl (hydrochloride)
Ivabradine metabolite N-Demethyl Ivabradine (hydrochloride)
3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one,hydrochloride
3-[3-[[[(7S)-3,4-DiMethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl]Methyl]aMino]propyl]-1,3,4,5-tetrahydro-7,8-diMethoxy-3-benzazepin-2-one Hydrochloride
(S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)amino)propyl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one hydrochloride | [Molecular Formula]
C26H35ClN2O5 | [MDL Number]
MFCD21363646 | [MOL File]
1246638-08-3.mol | [Molecular Weight]
491.019 |
| Chemical Properties | Back Directory | [Melting point ]
193-196°C | [storage temp. ]
Refrigerator | [solubility ]
DMF: 25 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): 10 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white | [Major Application]
pharmaceutical small molecule | [InChIKey]
MIIIKWNQFDQJGS-OZYVVJTJNA-N | [SMILES]
C([C@H]1CC2=CC(OC)=C(OC)C=C12)NCCCN1CCC2=CC(OC)=C(OC)C=C2CC1=O.Cl |&1:1,r| |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS09 | [Signal word ]
Warning | [Hazard statements ]
H400-H410 | [Precautionary statements ]
P273-P391-P501 | [WGK Germany ]
WGK 3 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Acute Tox. 4 Oral
Aquatic Chronic 2
Repr. 1B
STOT RE 2 |
| Hazard Information | Back Directory | [Description]
N-desmethyl Ivabradine is an active metabolite of ivabradine . Ivabradine is metabolized by the cytochrome P450 (CYP) isoform CYP3A4. | [Chemical Properties]
Beige Solid | [Uses]
Ivabradine (I940500) metabolite. | [References]
[1] GIAN MARCO ROSA. An evaluation of the pharmacokinetics and pharmacodynamics of ivabradine for the treatment of heart failure.[J]. Expert Opinion on Drug Metabolism & Toxicology, 2014, 10 2: 279-291. DOI: 10.1517/17425255.2014.876005 |
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Roark Standards
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