| Identification | Back Directory | [Name]
(S)-2-(6,7-DIHYDRO-5H-THIAZOLO[4,5-F]INDOL-2-YL)-4,5-DIHYDROTHIAZOLE-4-CARBOXYLIC ACID | [CAS]
1247879-16-8 | [Synonyms]
CYCLUC1
Luciferase substrate
CycLuc1(Luciferase substrate)
(S)-2-(6,7-DIHYDRO-5H-THIAZOLO[4,5-F]INDOL-2-YL)-4,5-DIHYDROTHIAZOLE-4-CARBOXYLIC ACID
Cyluc1 [(4S)-2-(6,7-Dihydro-5H-thiazolo[4,5-f]indol-2-yl)-4,5-dihydro-thiazole-4-carboxylic acid]
4-Thiazolecarboxylic acid, 2-(6,7-dihydro-5H-pyrrolo[3,2-f]benzothiazol-2-yl)-4,5-dihydro-, (4S)- | [Molecular Formula]
C13H11N3O2S2 | [MDL Number]
MFCD28133582 | [MOL File]
1247879-16-8.mol | [Molecular Weight]
305.38 |
| Chemical Properties | Back Directory | [Boiling point ]
606.8±65.0 °C(Predicted) | [density ]
1.84±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 83.33 mg/mL (272.87 mM) | [form ]
Solid | [pka]
3.54±0.20(Predicted) | [color ]
Yellow to brown |
| Hazard Information | Back Directory | [Uses]
Luciferase Substrate, CycLuc1 has been used for transfecting HEK293 cells to study the inhibition of intracellular luciferase crystallization by D-luciferin and its synthetic analogues. | [Biological Activity]
Cell permeable: yes''Primary Target
Luciferase | [in vivo]
CycLuc1 (0.05-5 mM, intraperitoneally injected) can improve bioluminescence imaging (BLI) of the existing luciferase reporter protein in mice and achieve brain imaging that D-luciferin cannot achieve[2].
| Animal Model: | Mouse xenograft tumor models[2] | | Dosage: | 0.05, 0.5, 1, 5 mM, 100 μL | | Administration: | i.p. | | Result: | Yielded a >10-fold higher bioluminescent signal than could be obtained from D-luciferin injection at equivalent doses. |
| [storage]
Store at -20°C |
|
| Company Name: |
Struchem Co., Ltd.
|
| Tel: |
0512-63009836 18994340901 |
| Website: |
www.beidapharma.com |
| Company Name: |
AOKBIO Inc.
|
| Tel: |
021-68712331 3286104197 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19166/0_EN.htm |
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