| Identification | Back Directory | [Name]
CD437 | [CAS]
125316-60-1 | [Synonyms]
CS-2691
ADAP-IME
CD 437/AHPN
AHPN;CD 437;CD-437
CD437;CD-437;CD 437
Adapalene IMpurity F
O-DesMethyl Adapalene
Apoptosis Activator VI
O-Desmethyl Adapalene-13C6
Apoptosis Activator VI, CD437/AHPN
6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthoic Acid
6-[3-(1-adamantyl)-4-hydroxyphenyl]naphthalene-2-carboxylic acid
Apoptosis Activator VI, CD437/AHPN - CAS 125316-60-1 - Calbiochem
AHPN, 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid
6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphenyl)-2-naphthalenecarboxylic
2-naphthalenecarboxylicacid,6-(4-hydroxy-3-tricyclo(3.3.1.1(3,7))dec-1-ylphen
2-Naphthalenecarboxylic acid, 6-(4-hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl)- | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C27H26O3 | [MDL Number]
MFCD03106506 | [MOL File]
125316-60-1.mol | [Molecular Weight]
398.49 |
| Chemical Properties | Back Directory | [Melting point ]
271.6-276 °C
| [Boiling point ]
595.0±50.0 °C(Predicted) | [density ]
1.290 | [storage temp. ]
-20°C | [solubility ]
DMSO: 26 mg/mL
| [form ]
solid
| [pka]
4.17±0.30(Predicted) | [color ]
yellow
| [InChI]
1S/C27H26O3/c28-25-6-5-22(20-1-2-21-11-23(26(29)30)4-3-19(21)10-20)12-24(25)27-13-16-7-17(14-27)9-18(8-16)15-27/h1-6,10-12,16-18,28H,7-9,13-15H2,(H,29,30) | [InChIKey]
LDGIHZJOIQSHPB-UHFFFAOYSA-N | [SMILES]
OC(=O)c1ccc2cc(ccc2c1)-c3ccc(O)c(c3)C45CC6CC(CC(C6)C4)C5 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
An intermediate in the preparation of Adapalene derivatives. | [Definition]
ChEBI: A naphthoic acid that is 6-phenylnaphthylene-2-carboxyic acid in which the phenyl substituent has been substituted at positions 3 and 4 by adamant-1-yl and hydroxy groups, respectively. It acts as a selective agonist of retinoic acid receptor (RAR)g
mma and induces cell cycle arrest and apoptosis in various cancer cells. | [Biological Activity]
Synthetic retinoid that is an RAR γ -selective agonist. Displays RAR γ -dependent and -independent effects on differentiation and apoptosis. | [Biochem/physiol Actions]
CD437 is a retinoic acid receptor (RAR)γ-selective agonist, γ-selective retinoid; potent inducer of apoptosis. | [storage]
Store at -20°C |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Adamas Reagent, Ltd.
|
| Telephone: |
4006009262 13023226327 |
| Website: |
http://www.tansoole.com |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Twochem Co.Ltd
|
| Telephone: |
021-021-58111628 15800915896 |
| Website: |
www.twochem.com |
|