| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
Soluble to 100 mM in water and to 5 mM in DMSO | [form ]
Powder | [color ]
Brown to reddish brown | [Water Solubility ]
Soluble to 100 mM in water |
| Hazard Information | Back Directory | [Uses]
JP 1302 Dihydrochloride is an α2-adrenoceptor blocker and can be used for the treatment or prevention of nephropathy. | [in vivo]
JP1302 (1-10 μmol/kg) decreases immobility time in the FST to a level similar to that seen with 10-30 μmol/kg of the antidepressant Desipramine (HY-B1272A)[1].
JP1302 (5 μmol/kg, once) is capable of complete reversal of the impairment in PPI induced in Sprague-Dawley rats by the psychotomimetic NMDA receptor antagonist, phencyclidine and similar results are found in Wistar rats[1].
JP1302 (3 mg/kg, IV, once) significantly ameliorates renal dysfunction[3]. | Animal Model: | Male Sprague Dawley rats (8 weeks old)[3] | | Dosage: | 3 mg/kg | | Administration: | IV, pre-treatment: administered 5 min before the induction of ischemia, post-treatment: injected 45 min after the initiation of reperfusion | | Result: | Significantly ameliorated renal dysfunction in the rats at 24 h after reperfusion. post-ischemic administration of JP-1302 significantly ameliorated renal dysfunction, histological damage and reduced apoptotic cells and pro-inflammatory cytokine mRNA expression. |
| [IC 50]
human α2C-adrenoceptor: 28±2 nM (Ki); human α2B-adrenoceptor: 1470±130 nM (Ki); human α2A-adrenoceptor: 3150±50 nM (Ki); rodent α2D-adrenoceptor: 1700±200 nM (Ki) | [storage]
Store at -20°C |
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| Company Name: |
BOC Sciences
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| Website: |
https://www.bocsci.com |
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