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1259484-97-3

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1259484-97-3 Structure

1259484-97-3 Structure
IdentificationBack Directory
[Name]

SKI 178
[CAS]

1259484-97-3
[Synonyms]

SKI 178
N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide
resistant,SphK,cytotoxic,myeloid,Inhibitor,Apoptosis,leukemia,multi-drug,inhibit,SKI-178,cancer,Sphingosine kinase,SKI178,drug,sensitive,cell,SKI 178
[Molecular Formula]

C21H22N4O4
[MOL File]

1259484-97-3.mol
[Molecular Weight]

394.42
Chemical PropertiesBack Directory
[density ]

1.24±0.1 g/cm3(Predicted)
[storage temp. ]

Store at -20°C
[solubility ]

DMF: 25 mg/ml; DMSO: 25 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/ml
[form ]

A crystalline solid
[pka]

9.25±0.46(Predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

SKI 178 is a sphingosine kinase 1 specific small-molecule inhibitor.
[in vivo]

SKI-178 (20 mg/kg; retro-orbital injection under isoflurane anesthesia) inhibits leukemic progression in the MLL-AF9 model[3].

Animal Model:MLL-AF9 mouse model (leukemic mice)[3]
Dosage:20 mg/kg
Administration:Retro-orbital injection under isoflurane anesthesia; three times per week for 1 and 3 weeks
Result:White blood cell (WBC) counts decreased from their initial 104 cells/μL levels and continued to decline after 3 weeks of treatment until they reached normal levels (~4×103 cells/μL).
[IC 50]

SphK1; SphK2
[storage]

Store at -20°C
Spectrum DetailBack Directory
[Spectrum Detail]

SKI 178(1259484-97-3)1HNMR
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