| Identification | Back Directory | [Name]
Ranitidinebismuthcitrate | [CAS]
128345-62-0 | [Synonyms]
Pylorid
Gastrimuto
Ranitidine bismutrex
RANTIDINEBISMUTHCITRATE
2-Hydroxy-1,2,3-propanetricarboxylic acid bismuth(3+) salt compd with N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C13H22N4O3S.C6H5O7.Bi | [MDL Number]
MFCD00891318 | [MOL File]
128345-62-0.mol | [Molecular Weight]
506.53 |
| Questions And Answer | Back Directory | [Preparation]
① A solution containing Ranitidinebismuthcitrate is obtained by reacting ranitrate with ranitrate at 90–95°C; ② The solution containing Ranitidinebismuthcitrate obtained in step ① is cooled to 50–60°C, activated carbon is added, and the solution is kept at this temperature for decolorization for 20–30 minutes; ③ The solution is filtered, the filtrate is added to self-made anhydrous ethanol and stirred to crystallize, then filtered again. The filter cake is dried to obtain Ranitidinebismuthcitrate. |
| Hazard Information | Back Directory | [Uses]
Antagonist (to histamine H2receptors). | [Brand name]
Tritec (GlaxoSmithKline). | [Hazard]
A poison by ingestion.
| [Description]
Ranitidine bismuth citrate, a novel salt formed from ranitidine and a bismuth
citrate complex, is a new agent introduced in the United Kingdom for the
treatment of duodenal and benign gastric ulcers, for eradication of Helicobacfer pylori,
and for prevention of relapse of duodenal ulcer when administered in combination with
an antibiotic such as clarithromycin or amoxicillin. Ranitidine is a potent histamine H2-receptor
antagonist with ability to inhibit gastric acid secretion. Other type of agents
such as tripotassium dicitrato bismuthate exert their therapeutic effects in peptic
ulceration by providing a protective coating to the ulcer crater, stimulating endogenous
prostaglandin production, and inhibiting pepsin activity. More significantly, they inhibit
micro-organism Helicobacfer pylori, a prevalent, specifically human pathogen
associated with gastritis and gastric ulcers. The title compound possesses a novel
combination of properties of the above two types of drugs and displays excellent
therapeutic efficacy in clinical studies. Ranitidine bismuth citrate is being investigated
for use in gastritis and non-ulcerating dyspepsia, acute healing of gastrointestinal ulcer
and in prevention of the recurrence of peptic ulcer disease. | [Originator]
Glaxo Wellcome (United Kingdom) | [Mechanism of action]
Ranitidine bismuth citrate has been
developed for combination therapy with antibiotics
for eradication of H.p. Depending on the
co-prescription, eradication ranged from 15 to
92 % in an intention-to-treat analysis . It is
claimed to combine the antisecretory action of
ranitidine with the antimicrobial and gastroprotective
actions of bismuth. |
|
| Company Name: |
AFINE CHEMICALS LIMITED
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| Telephone: |
+86-571-85134551 +86-18958018566 |
| Website: |
www.afinechem.com/index.html |
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