| Identification | More | [Name]
1-Hydroxy anthraquinone | [CAS]
129-43-1 | [Synonyms]
1-hydroxy-9,10-anthracenedione
1-HYDROXYANTHRAQUINONE
4-HYDROXYANTHRAQUINONE
10-Anthracenedione,1-hydroxy-9
1-hydroxy-10-anthracenedione
1-Hydroxy-9,10-anthraquinone
1-Hydroxyanthra-9,10-quinone
1-Hydroxyanthrachinon
1-hydroxy-anthraquinon
alpha-Hydroxyanthraquinone
Anthraquinone, 1-hydroxy-
I-0syanthrachinon
1-hydroxyanthracene-9,10-dione
NISTC129431
erythroxyanthraquinone | [EINECS(EC#)]
204-946-7 | [Molecular Formula]
C14H8O3 | [MDL Number]
MFCD00058946 | [Molecular Weight]
224.21 | [MOL File]
129-43-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
194°C | [Boiling point ]
325.61°C (rough estimate) | [density ]
1.2337 (rough estimate) | [refractive index ]
1.5400 (estimate) | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Chloroform: 30 mg/ml | [form ]
powder to crystal | [pka]
7.15±0.20(Predicted) | [color ]
Light yellow to Brown | [InChI]
1S/C14H8O3/c15-11-7-3-6-10-12(11)14(17)9-5-2-1-4-8(9)13(10)16/h1-7,15H | [InChIKey]
BTLXPCBPYBNQNR-UHFFFAOYSA-N | [SMILES]
Oc1cccc2C(=O)c3ccccc3C(=O)c12 | [CAS DataBase Reference]
129-43-1(CAS DataBase Reference) | [IARC]
2B (Vol. 82) 2002 | [NIST Chemistry Reference]
9,10-Anthracenedione, 1-hydroxy-(129-43-1) | [EPA Substance Registry System]
129-43-1(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
WGK 3 | [RTECS ]
CB7178000 | [TSCA ]
TSCA listed | [HS Code ]
2914.69.9000 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Carc. 2
Eye Irrit. 2 | [Hazardous Substances Data]
129-43-1(Hazardous Substances Data) |
| Hazard Information | Back Directory | [Uses]
1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect[1]. | [Definition]
ChEBI: 1-hydroxyanthraquinone is a monohydroxyanthraquinone. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 55, p. 350, 1990 DOI: 10.1021/jo00288a062 | [in vivo]
1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats[1]. | Animal Model: | Thirty rats[1]. | | Dosage: | 1% HA in diet. | | Administration: | Diet. | | Result: | Associated with decreased weight gain which was particularly marked towards the termination of experiment.
One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment.
A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon.
Seven animals of the group died spontaneously or were sacrificed upon becoming
moribund between 335 and 462 days.
A total of 21 rats of group 1 survived until the end of experiment (mean value of total
intake of HA/rat was 76.8 g).
|
| [References]
[1] H Mori, et al. Carcinogenicity of naturally occurring 1-hydroxyanthraquinone in rats: induction of large bowel, liver and stomach neoplasms. Carcinogenesis. 1990 May;11(5):799-802. DOI:10.1093/carcin/11.5.799 |
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