| Identification | Back Directory | [Name]
Amino-PEG10-alcohol | [CAS]
129449-09-8 | [Synonyms]
129449-09-8
H2N-PEG10-OH
Amino-PEG10-OH
Amino-PEG10-alcohol
3,6,9,12,15,18,21,24,27-Nonaoxanonacosan-1-ol, 29-amino- | [Molecular Formula]
C20 H43 N O10 | [MDL Number]
MFCD28385478 | [MOL File]
129449-09-8.mol | [Molecular Weight]
457.56 |
| Chemical Properties | Back Directory | [Boiling point ]
533.3±45.0 °C(Predicted) | [density ]
1.096±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20 °C | [pka]
14.36±0.10(Predicted) | [Appearance]
light yellow liquid | [InChI]
InChI=1S/C20H43NO10/c21-1-3-23-5-7-25-9-11-27-13-15-29-17-19-31-20-18-30-16-14-28-12-10-26-8-6-24-4-2-22/h22H,1-21H2 | [InChIKey]
OXOVKDXWDUGJLC-UHFFFAOYSA-N | [SMILES]
C(O)COCCOCCOCCOCCOCCOCCOCCOCCOCCN |
| Hazard Information | Back Directory | [Description]
Amino-PEG10-alcohol is a highly water soluble PEG reagent. The amine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. | [Biological Activity]
Amino-PEG10-OH is a non-cleavable 10-unit PEG-ADC linker for antibody drug-drug (ADC) synthesis. It is also a PEG-based PROTAC linker that can be used for PROTAC synthesis. | [in vitro]
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. | [target]
| Non-cleavable < span> | PEGs | |
|
| Company Name: |
Wuhan Topule Gold
|
| Telephone: |
+86-02787215551 19945035818 |
| Website: |
http://www.topule.com/ |
| Company Name: |
T&W GROUP
|
| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
| Company Name: |
Henan Alfachem Co.,Ltd.
|
| Telephone: |
0371-55051623 18137891487 |
| Website: |
www.chemicalbook.com/supplier/14555231/ |
| Company Name: |
Labnetwork lnc.
|
| Telephone: |
+86-27-50766799 +86-18062016861 |
| Website: |
www.labnetwork.com |
| Company Name: |
Nextpeptide Inc
|
| Telephone: |
+86-0571-81612335 +8613336028439 |
| Website: |
http://www.nextpeptide.com/ |
|