| Identification | Back Directory | [Name]
alpha, oMega-Dipropionic acid triethylene glycol | [CAS]
31127-85-2 | [Synonyms]
Bis-PEG4-acid
Bis-PEG5-acid
Bis-PEG4-COOH
HOOC-PEG3-COOH
COOH-PEG3-COOH
CH2COOH-PEG2-CH3COOH
COOH-CH2-PEG3-CH2-COOH
HOOCCH2CH2O-PEG3 -CH2CH2COOH
4,7,10,13-Tetraoxahexadecanedioic acid
α,ω-Dipropionic acid triethylene glycol
4,7,10,13-Tetraoxahexadecane-1,16-dioic acid
Apha, omega-Dipropionic acid triethylene glycol
alpha, oMega-Dipropionic acid triethylene glycol
4,7,10,13-Tetraoxa-hexadecan-1,16-dicarbonsaeure
"lpha, oMega-Dipropionic acid triethylene glycol"
3-[2-[2-[2-(2-carboxyethoxy)ethoxy]ethoxy]ethoxy]propanoic acid | [EINECS(EC#)]
228-394-1 | [Molecular Formula]
C12H22O8 | [MDL Number]
MFCD22201545 | [MOL File]
31127-85-2.mol | [Molecular Weight]
294.3 |
| Chemical Properties | Back Directory | [Boiling point ]
483.7±45.0 °C(Predicted) | [density ]
1.219±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Soluble in Water, DMSO, DCM, DMF | [form ]
Oil | [pka]
3.97±0.10(Predicted) | [color ]
Colorless to off-white |
| Hazard Information | Back Directory | [Description]
Bis-PEG4-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. | [Uses]
Bis-PEG4-acid is a PEG PROTAC linker. | [IC 50]
PEGs | [References]
[1] Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830. DOI:10.1038/s41467-017-00954-1 |
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