| Identification | Back Directory | [Name]
Protopine | [CAS]
130-86-9 | [Synonyms]
Protopin
BIFLORIN
Biflorine
PROTOPINE
Corydinine
Tangeratin
Corydalis C
Hypercorine
AKOS 243-72
Protopine USP/EP/BP
Protopine (Corydinine)
4,6,7,14-Tetrahydro-5-Methyl-
5,7-DIHYDROXY-2-METHYLCHROMONE-6-C-BETA-D-GLUCOPYRANOSIDE
7-Methyl-2,3:9,10-bis(methylenedioxy)-7,13a-secoberbin-13a-one
7,13a-Secoberbin-13a-one, 7-methyl-2,3:9,10-bis(methylenedioxy)-
Protopine, 98%, from Corydalis yanhusuo W. T. Wang ex Z. Y. Su et C. Y. Wu
7-Methyl-6,8,9,16-tetrahydrodi[1,3]benzodioxolo[4,5-c:5,6-g]azecin-15(7H)-one
4,6,7,14-Tetrahydro-5-methyl-bis[1,3]benzodioxolo[4,5-c-5',6'-g] azecin-13(5H)-one
Bis[1,3]benzodioxolo[4,5-c:5',6'-g]azecin-13(5H)-one, 4,6,7,14-tetrahydro-5-methyl-
5-Methyl-9,10-(methylenedioxy)-4,6,7,13-tetrahydrobenzo[e]-1,3-dioxolo[4,5-l][2]benzazecine-12(5H)-one
6-Methyl-3,4-(methylenebisoxy)-10,11-(methylenebisoxy)-5,6,7,8-tetrahydrodibenzo[c,g]azecine-13(14H)-one
7-Methyl-6,7,8,9-tetrahydro-[1,3]dioxolo[4',5':5,6]benzo[1,2-c][1,3]dioxolo[5',4':4,5]benzo[1,2-g]azecin-15(16H)-one | [EINECS(EC#)]
204-999-6 | [Molecular Formula]
C20H19NO5 | [MDL Number]
MFCD00022322 | [MOL File]
130-86-9.mol | [Molecular Weight]
353.37 |
| Chemical Properties | Back Directory | [Melting point ]
203-205?C | [Boiling point ]
486.8°C (rough estimate) | [density ]
1.399 (calc) | [refractive index ]
1.5800 (estimate) | [storage temp. ]
Refrigerator | [solubility ]
DMSO : 12.5 mg/mL (35.37 mM; Need ultrasonic) | [Water Solubility ]
Insoluble in water | [form ]
powder to crystal | [pka]
7.86±0.20(Predicted) | [color ]
White to Light gray to Light yellow | [Major Application]
food and beverages | [InChI]
InChI=1S/C20H22NO5/c1-25-11-23-17-5-4-13-2-3-14-9-19-18(24-12-26(19)22)8-15(14)6-7-21-10-16(13)20(17)25/h2-5,8,16,21H,6-7,9-12H2,1H3/b13-2-,14-3- | [InChIKey]
JVVZZYVMOGCQIP-JAIUMMMNSA-N | [SMILES]
N1CCC2=CC3OCO(=O)C=3CC2=CC=C2C=CC3OCO(C)C=3C2C1 |c:14,t:16| | [LogP]
3.760 (est) | [NIST Chemistry Reference]
Protopine(130-86-9) |
| Safety Data | Back Directory | [Safety Statements ]
24/25 | [RIDADR ]
1544 | [WGK Germany ]
WGK 3 | [RTECS ]
VS2800000 | [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29391900 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral | [Hazardous Substances Data]
130-86-9(Hazardous Substances Data) | [Toxicity]
guinea pig,LD50,intraperitoneal,116mg/kg (116mg/kg),Therapie. Vol. 28, Pg. 767, 1973. |
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Uses]
Protopine is a Ca2+ channel blocker and antiplatelet agent. Immunomodulator | [Definition]
ChEBI: A dibenzazecine alkaloid isolated from Fumaria vaillantii. | [General Description]
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG | [Enzyme inhibitor]
This photosensitive antiplatelet agent (FWfree-base = 353.37 g/mol; CAS 130-
86-9) from a number of plants, including the herb Fumaria officinalis and
opium, is a Ca2+ channel blocker. Protopine is commonly supplied
commercially as the hydroc2+hloride or the methiodide. Target (s) :
acetylcholinesterase; Ca channels; cation channel currents,
including ICa,L, IK, IK1, as well as INa; certain cytochrome P450 systems
; phospholipase; and thromboxane synthase. | [Purification Methods]
It crystallises from EtOH/CHCl3. The picrate has m ~240o(dec). [Beilstein 27 H 558, 17 I 568, 17 II 620, 17 III/IV 6881.] |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
China Langchem Inc.
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| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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