| Identification | Back Directory | [Name]
L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N-[1-(diphenoxyphosphinyl)-2-methylpropyl]- | [CAS]
130727-21-8 | [Synonyms]
L-Prolinamide, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-N-[1-(diphenoxyphosphinyl)-2-methylpropyl]- | [Molecular Formula]
C31H44N3O7P | [MOL File]
130727-21-8.mol | [Molecular Weight]
601.67 |
| Chemical Properties | Back Directory | [Melting point ]
62-66 °C | [Boiling point ]
751.1±60.0 °C(Predicted) | [density ]
1.185±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.49±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
JO146 is a Chlamydia trachomatis high temperature requirement A (CtHtrA) protease inhibitor with IC50s of 21.86 and 1.15 μM for CtHtrA and human neutrophil elastase (HNE), respectively. JO146 can be used to inhibits bacterial infections[1]. | [References]
[1] Jimin Hwang, et al. Design, synthesis and biological evaluation of P2-modified proline analogues targeting the HtrA serine protease in Chlamydia. Eur J Med Chem. 2022 Feb 15;230:114064. DOI:10.1016/j.ejmech.2021.114064 |
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