| Identification | Back Directory | [Name]
DECURSINOL ANGELATE | [CAS]
130848-06-5 | [Synonyms]
Acutilobin
Decursinol mebutate
DECURSINOL ANGELATE
2-Butenoic acid, 2-methyl-, (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b']dipyran-7-yl ester, (2Z)- | [Molecular Formula]
C19H20O5 | [MDL Number]
MFCD06796687 | [MOL File]
130848-06-5.mol | [Molecular Weight]
328.36 |
| Chemical Properties | Back Directory | [Melting point ]
93-94 °C | [Boiling point ]
469.4±45.0 °C(Predicted) | [density ]
1.24±0.1 g/cm3(Predicted) | [storage temp. ]
4°C, protect from light | [solubility ]
DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml | [form ]
A crystalline solid | [color ]
White to off-white | [InChI]
1S/C19H20O5/c1-5-11(2)18(21)23-16-9-13-8-12-6-7-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/b11-5-/t16-/m0/s1 | [InChIKey]
AGABNGOXUSXQDD-XKGFZTIGSA-N | [SMILES]
[o]1c2c(cc3c(c2)OC([C@H](C3)OC(=O)\C(=C/C)\C)(C)C)cc[c]1=O |
| Hazard Information | Back Directory | [Uses]
Decursinol angelate, a cytotoxic and protein kinase C (PKC) activating agent from the root of Angelica gigas, possesses anti-tumor and anti-inflammatory activities[1][2]. | [Biological Activity]
Decursinol Angelate is a pyranocoumarin isolated from medical plant Angelica gigas th at exhibits potent anti-inflammatory properties. Decursinol Angelate appears to suppress type 17 helper T (Th17) cell responses in dextran sodium sulfate-induced colitis model. Decursinol Angelate reduces the production of NF-KB and COX-2 induced proinflammatory cytokine levels on TPA induced mice ear edema. | [References]
[1] Ahn KS, et al. Decursinol angelate: a cytotoxic and protein kinase C activating agent from the root of Angelica gigas. Planta Med. 1997 Aug;63(4):360-1. DOI:10.1055/s-2006-957701
[2] Lee S, et al. Anti-tumor activities of decursinol angelate and decursin from Angelica gigas. Arch Pharm Res. 2003 Sep;26(9):727-30. DOI:10.1007/BF02976682 |
|
|