| Identification | Back Directory | [Name]
Amino-PEG8-azide | [CAS]
1333154-77-0 | [Synonyms]
N3-PEG7-NH2
1333154-77-0
Azido-PEG7-NH2
Amino-PEG8-azide
Azido-PEG7-amine
Azido-dPEG7-amine
Azido-dPEG??-amine
Azido-dPEG(R)7-amine
23-Azido-3,6,9,12,15,18,21-heptaoxatricosan-1-amine | [Molecular Formula]
C16H34N4O7 | [MDL Number]
MFCD13185016 | [MOL File]
1333154-77-0.mol | [Molecular Weight]
394.464 |
| Chemical Properties | Back Directory | [storage temp. ]
-20°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
solid or viscous liquid | [color ]
Light Yellow to Light Beige | [InChI]
1S/C16H34N4O7/c17-1-3-21-5-7-23-9-11-25-13-15-27-16-14-26-12-10-24-8-6-22-4-2-19-20-18/h1-17H2 | [InChIKey]
VZKXLNRXAFTBOW-UHFFFAOYSA-N | [SMILES]
NCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-] |
| Hazard Information | Back Directory | [Description]
Azido-dPEG7-amine is a heterobifunctional PEGylated linker. It contains a reactive NH2 end group, as well as an azide functional group for use in click chemistry reactions. Azido-dPEG7-amine has been used as a linker in the synthesis of bivalent mammalian target of rapamycin (mTOR) inhibitors. | [Uses]
Azido-PEG7-amine is used in methods for detecting assay interferences and increasing dynamic range. | [reaction suitability]
reaction type: click chemistry
reagent type: cross-linking reagent
reaction type: click chemistry | [IC 50]
Non-cleavable Linker; PEGs | [References]
[1] GOSWAMI L N, HOUSTON Z H, SARMA S J, et al. Efficient synthesis of diverse heterobifunctionalized clickable oligo(ethylene glycol) linkers: potential applications in bioconjugation and targeted drug delivery?[J]. Organic & Biomolecular Chemistry, 2012, 7: 1116-1126. DOI: 10.1039/c2ob26968f
[2] VANESSA S. RODRIK-OUTMEZGUINE. Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor[J]. Nature, 2016, 534 7606: 272-276. DOI: 10.1038/nature17963 |
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Sigma-Aldrich
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