| Identification | Back Directory | [Name]
H2N-PEG6-tBu | [CAS]
1286281-32-0 | [Synonyms]
H2N-PEG6-tBu
NH2-PEG6-Boc
1286281-32-0
Amino-PEG6-COOtBu
H2N-PEG6-CH2CH2COOtBu
NH2-PEG6-CH2CH2COOtBu
Amino-PEG6-t-butyl ester
Amino-PEG7-t-butyl ester
Amino-dPEG??-t-butyl ester
H2N-PEG6-CH2CH2-t-butylester
t-Butyl 3-Amino(peg6)propionate
Amino-PEG6-t-butylester,H2N-PEG6-t-butyl ester
tert-Butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate
4,7,10,13,16,19-Hexaoxaheneicosanoic acid, 21-amino-, 1,1-dimethylethyl ester | [Molecular Formula]
C19H39NO8 | [MDL Number]
MFCD13184944 | [MOL File]
1286281-32-0.mol | [Molecular Weight]
409.51 |
| Hazard Information | Back Directory | [Description]
Amino-PEG6-t-butyl ester is a PEG reagent containing an amino NH2 group with a t-butyl protected carboxyl group (Boc). The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. |
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