| Identification | Back Directory | [Name]
H2N-PEG6-tBu | [CAS]
1286281-32-0 | [Synonyms]
H2N-PEG6-tBu
NH2-PEG6-Boc
1286281-32-0
Amino-PEG6-COOtBu
H2N-PEG6-CH2CH2COOtBu
NH2-PEG6-CH2CH2COOtBu
Amino-PEG6-t-butyl ester
Amino-PEG7-t-butyl ester
Amino-dPEG??-t-butyl ester
H2N-PEG6-CH2CH2-t-butylester
t-Butyl 3-Amino(peg6)propionate
Amino-PEG6-t-butylester,H2N-PEG6-t-butyl ester
tert-Butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate
4,7,10,13,16,19-Hexaoxaheneicosanoic acid, 21-amino-, 1,1-dimethylethyl ester | [Molecular Formula]
C19H39NO8 | [MDL Number]
MFCD13184944 | [MOL File]
1286281-32-0.mol | [Molecular Weight]
409.51 |
| Chemical Properties | Back Directory | [Boiling point ]
475.9±40.0 °C(Predicted) | [density ]
1.056±0.06 g/cm3(Predicted) | [refractive index ]
n/D 1.4562 | [storage temp. ]
-20°C | [form ]
Oil | [pka]
8.74±0.10(Predicted) | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C19H39NO8/c1-19(2,3)28-18(21)4-6-22-8-10-24-12-14-26-16-17-27-15-13-25-11-9-23-7-5-20/h4-17,20H2,1-3H3 | [InChIKey]
QGSFECNPSLZGGT-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)CCOCCOCCOCCOCCOCCOCCN |
| Hazard Information | Back Directory | [Description]
Amino-PEG6-t-butyl ester is a PEG reagent containing an amino NH2 group with a t-butyl protected carboxyl group (Boc). The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG6-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation. | [General Description]
H2N-PEG6-tBu (CAS 1286281-32-0) is a high-purity, PEG-based PROTAC linker suitable for the synthesis of PROTACs. It has a molecular weight of 409.51 and appears as a colourless to pale yellow viscous liquid or a low-melting-point waxy solid at room temperature. Synonyms include Amino-PEG6-t-butyl ester, NH₂-PEG6-CH₂CH₂COO-tBu, NH₂-PEG6-Boc, H₂N-PEG6-CH₂CH₂COO-tBu and Amino-PEG6-COO-tBu, amongst others. | [reaction suitability]
reagent type: cross-linking reagent | [IC 50]
PEGs; Alkyl/ether; Non-cleavable Linker |
|
| Company Name: |
T&W GROUP
|
| Telephone: |
021-61551611 13296011611 |
| Website: |
www.trustwe.com/ |
| Company Name: |
Sigma-Aldrich
|
| Telephone: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Borenpharm Co., Ltd
|
| Telephone: |
027-65563561 13026317987; |
| Website: |
http://www.borenpharm.com |
|