| Identification | More | [Name]
4-METHOXY-1-INDANONE | [CAS]
13336-31-7 | [Synonyms]
4-METHOXY-1-INDANONE
4-METHOXY-INDAN-1-ONE
4-METHOXY-1-INDANONE 99%
4-Methoxyindanone | [Molecular Formula]
C10H8O2 | [MDL Number]
MFCD00192268 | [Molecular Weight]
160.17 | [MOL File]
13336-31-7.mol |
| Chemical Properties | Back Directory | [Appearance]
white to light yellow crystal powder | [Melting point ]
105-107 °C (dec.) (lit.) | [Boiling point ]
115-120 °C/0.5 mmHg (lit.) | [density ]
1.0281 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [InChI]
InChI=1S/C10H10O2/c1-12-10-4-2-3-7-8(10)5-6-9(7)11/h2-4H,5-6H2,1H3 | [InChIKey]
BTYSYELHQDGJAB-UHFFFAOYSA-N | [SMILES]
C1(=O)C2=C(C(OC)=CC=C2)CC1 | [CAS DataBase Reference]
13336-31-7(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
white to light yellow crystal powder | [Uses]
4-Methoxy-1-indanone is suitable for use in the comparative study of the effect of different substituents on various benzo-fused ketones on the reaction kinetics by studying the biocatalysed oxidation reaction.
It may be used in the following studies:
- Synthesis of isomeric mixture of oximes.
- As a starting material in the synthesis of benzo-fused indolizidine and 4-methoxy-1-indanyl compound.
- Synthesis of 4-methoxy-5-nitro-1-indanone by nitration reaction.
- As one of the reactant in the synthesis of E-2-chloro-8-methyl-3-[(4′-methoxy-1′-indanoyl)-2′-methyliden]-quinoline (IQ), a quinoline derivative.
| [General Description]
4-Methoxy-1-indanone, a benzo-fused ketone is a 1-indanone derivative. Its synthesis has been reported. | [Synthesis]
The reaction was carried out with 4-hydroxy-1-indanone (125 mg) and iodomethane (263 μL) in the presence of potassium carbonate (350 mg) in N,N-dimethylformamide (DMF, 4 mL) for 3 h at 50 °C with stirring. After completion of the reaction, the mixture was poured into 1N hydrochloric acid (20 mL) and extracted with ether (4 × 10 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give 4-methoxy-1-indanone intermediate as a clear oil (131 mg, 96% yield). Mass spectral analysis showed [MH]+ = 163. | [References]
[1] Chemical and Pharmaceutical Bulletin, 1994, vol. 42, # 9, p. 1756 - 1759
[2] Patent: US2006/173183, 2006, A1. Location in patent: Page/Page column 114
[3] European Journal of Medicinal Chemistry, 2013, vol. 69, p. 920 - 930
[4] Patent: WO2014/19344, 2014, A1. Location in patent: Paragraph 00821
[5] Patent: WO2014/82380, 2014, A1. Location in patent: Paragraph 00314; 00316 |
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