| Identification | Back Directory | [Name]
Ethanone, 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)- | [CAS]
1337532-14-5 | [Synonyms]
PERK-IN-6
Ethanone, 1-[5-(4-amino-7-methyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2,3-dihydro-1H-indol-1-yl]-2-(6-methyl-2-pyridinyl)- | [Molecular Formula]
C23H22N6O | [MOL File]
1337532-14-5.mol | [Molecular Weight]
398.46 |
| Chemical Properties | Back Directory | [Boiling point ]
746.2±60.0 °C(Predicted) | [density ]
1.38±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
5.76±0.30(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
PERK-IN-6 (Compound 5) is a PERK inhibitor with an IC50 of 2.5 nM[1]. | [in vivo]
The rat blood clearance of PERK-IN-6 (Compound 5) is 10.5 mL/min/kg after i.v infusion in SD rats[1]. | [References]
[1] Axten JM, et al. Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development. ACS Med Chem Lett. 2013 Aug 12;4(10):964-8. DOI:10.1021/ml400228e |
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