| | Identification | Back Directory |  | [Name] 
 BETA-GLYCEROL PHOSPHATE DISODIUM SALT
 |  | [CAS] 
 13408-09-8
 |  | [Synonyms] 
 β-Glycerophosphate
 Sodium B Glycerophosphate
 Disodium β-glycerol phosphate
 trichloromethyl carbonochloridate
 beta-Glycerophosphate, 200mM soln
 Sodium--glycerophosphate, GR 99%+
 β-Glycerol phosphate disodium salt
 Two sodiuMglycerophosphatefivewater
 BETA-GLYCEROPHOSPHATE DISODIUM SALT
 BETA-GLYCEROL PHOSPHATE DISODIUM SAL
 BETA-GLYCEROL PHOSPHATE DISODIUM SALT
 BETA- LYCEROL PHOSPHATE DISODIUM SALT
 SODIUM B-GLYCEROPHOSPHATE PENTAHYDRATE
 sodium á-glycerophosphate pentahydrate
 SODIUM SS-GLYCEROPHOSPHATE PENTAHYDRATE
 BLUE DUO PROTEIN MARKER, LOW RANGE BIOT
 Disodium β-Glycerophosphate Pentahydrate
 β-Glycerophosphate (sodium salt hydrate)
 Disodium β-Glycerophosphate Pentahydrate
 SodiuM 1,3-dihydroxypropan-2-yl phosphate
 Disodiumβ-GlycerophosphatePentahydrate>
 chlorocarbonic acid trichloromethyl ester
 DisodiuM β-glycerol phosphate pentahydrate
 disodium 2-(phosphonatooxy)propane-1,3-diol
 β-Glycerophosphate disodium salt pentahydrate
 beta-Glycerophosphate disodium salt 5-hydrate
 .beta.-Glycerophosphate (sodium salt hydrate)
 Disodium beta-glycerol phosphate pentahydrate
 á-glycerol phosphate disodium salt pentahydrate
 β-Glycerol phosphate disodium salt pentahydrate
 -β-Glycerol Phosphate Disodium Salt Pentahydrate
 b-Glycerophosphate disodium salt pentahydrate 97+%
 β-glycerophosphoric acid disodium salt pentahydrate
 β-Glycerol  phosphate  pentahydrate  disodium  salt
 beta-Glycerophosphoric acid disodium salt pentahydrate
 SodiuM 1,3-dihydroxypropan-2-yl phosphate pentahydrate
 beta-Glycerophosphate, disodium salt pentahydrate, max. 2% alpha
 Disodiumβ-GlycerophosphatePentahydrate[forBiochemicalResearch]>
 DisodiuM β-Glycerophosphate Pentahydrate [for BiocheMical Research]
 DisodiuM beta-Glycerophosphate Pentahydrate [for BiocheMical Research]
 β-Glycerol phosphate disodium salt pentahydrate,Disodium β-glycerol phosphate
 Disodium β-glycerol phosphate
Glycerol 2-Phosphate Disodium Salt 
β-Glycerophosphoric Acid Disodium Salt
 |  | [EINECS(EC#)] 
 639-414-7
 |  | [Molecular Formula] 
 C3H7Na2O6P
 |  | [MDL Number] 
 MFCD00149083
 |  | [MOL File] 
 13408-09-8.mol
 |  | [Molecular Weight] 
 216.037
 | 
 | Chemical Properties | Back Directory |  | [Melting point ] 
 >300°C
 |  | [storage temp. ] 
 2-8°C
 
 |  | [solubility ] 
 H2O: 0.1 g/mL, clear, colorless
 
 |  | [form ] 
 White powder
 |  | [color ] 
 Whiteto Off-White
 |  | [Water Solubility ] 
 Soluble in water.
 |  | [Merck ] 
 14,8622
 |  | [BRN ] 
 3744328
 |  | [Stability:] 
 Hygroscopic
 |  | [InChI] 
 InChI=1S/C3H9O6P.Na.H2O.H/c4-1-3(2-5)9-10(6,7)8;;;/h3-5H,1-2H2,(H2,6,7,8);;1H2;
 |  | [InChIKey] 
 PEMUISUYOHQFQH-UHFFFAOYSA-L
 |  | [SMILES] 
 O(P(O)(O)=O)C(CO)CO.[NaH].O
 | 
 | Hazard Information | Back Directory |  | [Description] 
 β-Glycerophosphate is a protein phosphatase inhibitor that acts as a phosphate group donor in matrix mineralization studies.1,2,3 It promotes bone matrix mineralization when delivered to osteoblasts by providing a source of phosphate ions.1 β-Glycerophosphate (10 mM) accelerates calcification of cultured vascular smooth muscle cells through an alkaline phosphatase-related mechanism.4
 |  | [Chemical Properties] 
 Solid
 |  | [Uses] 
 β-Glycerol Phosphate was shown to have promoted mineralization in vitro by modulating bone cell metabolic activity and/or serving as a local source of inorganic phosphate ions.
 |  | [General Description] 
 
 A phosphate group donor in matrix mineralization studies. Accelerates calcification in vascular smooth muscle cells. Also acts as a protein phosphatase inhibitor. |  | [Biochem/physiol Actions] 
 Beta-Glycerophosphate is a classical serine-threonine phosphatase inhibitor used in kinase reaction buffers. BGP is often used in combination with other phosphatase/protease inhibitors for broad spectrum inhibition. It functions as an organic phosphate donor and has been used in culture media for mesenchymal stem cell differentiation to osteoblast-type cells. BGP is also used to buffer M17 media for Lactococcus culture in recombinant protein expression
 |  | [Purification Methods] 
 Crystallise it from water. [Attwood et al. Biochem J 253 389 1988, Beilstein 1 IV 2766.]
 |  | [References] 
 [1].  chung ch, golub ee, forbes e, et al. mechanism of action of beta-glycerophosphate on bone cell mineralization. calcif tissue int. 1992 oct;51(4):305-11.
 [2].  fujimoto h, mabuchi i. isolation of cleavage furrows from eggs of regular sea urchins and identification of furrow-specific proteins. j biochem. 1997 sep;122(3):518-24.
 [3].  lecanda f, avioli lv, cheng sl. regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2. j cell biochem. 1997 dec 1;67(3):386-96.
 [4].  shioi a, nishizawa y, jono s, et al. beta-glycerophosphate accelerates calcification in cultured bovine vascular smooth muscle cells. arterioscler thromb vasc biol. 1995 nov;15(11):2003-9.
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