| Identification | Back Directory | [Name]
(+)-CP 47,497 | [CAS]
134308-14-8 | [Synonyms]
(+)-CP 47,497
Phenol, 5-(1,1-dimethylheptyl)-2-[(1R,3S)-3-hydroxycyclohexyl]- | [Molecular Formula]
C21H34O2 | [MOL File]
134308-14-8.mol | [Molecular Weight]
318.49 |
| Hazard Information | Back Directory | [Uses]
(+)-CP 47,497 is a bicyclic CB analog with potent analgesic activity.Synthetic Cannabinoids | [Uses]
CP 47,497 is a bicyclic CB analog with potent analgesic activity. It is comparable or more potent than Δ9-tetrahydrocannabinol in analgesic, motor depressant, anticonvulsant, and hypothermic effects in mice, rats, and dogs. The dextrorotatory enantiomer, (+)-CP 47,497 avidly binds the CB1 receptor (Ki = 4.15 nM).[Cayman Chemical] | [References]
[1] LAWRENCE S. MELVIN. A cannabinoid derived prototypical analgesic[J]. Journal of Medicinal Chemistry, 1984, 27 1: 67-71. DOI: 10.1021/jm00367a013
[2] A WEISSMAN L S M G M Milne. Cannabimimetic activity from CP-47,497, a derivative of 3-phenylcyclohexanol.[J]. Journal of Pharmacology and Experimental Therapeutics, 1982, 223 2: 516-523.
[3] L S MELVIN. Structure-activity relationships defining the ACD-tricyclic cannabinoids: cannabinoid receptor binding and analgesic activity.[J]. Drug design and discovery, 1995, 13 2: 155-166.
[4] S E DAMODARAN S M. Telavancin: A novel lipoglycopeptide antibiotic.[J]. Journal of Pharmacology & Pharmacotherapeutics, 2011, 2 2: 135-137. DOI: 10.4103/0976-500x.81918 |
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