| Identification | Back Directory | [Name]
5,7-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6-methoxy-chromen-4-one | [CAS]
18085-97-7 | [Synonyms]
Jacosidin
JACEOSIDIN
Jacesiolin
Jaseosidin
6-Hydroxyluteolin 3',6-dimethyl ether
4',5,7-Trihydroxy-3',6-dimethoxyflavone
3',6-Dimethoxy-4',5,7-trihydroxyflavone
5,7-dihydroxy-2-(4-hydroxy-3-methoxy-phenyl)-6-methoxy-chromen-4-one
5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-chromen-4-one
5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxy-
4',5,7-Trihydroxy-3',6-dimethoxyflavone
5,7-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-6-methoxychromen-4-one | [Molecular Formula]
C17H14O7 | [MDL Number]
MFCD01081948 | [MOL File]
18085-97-7.mol | [Molecular Weight]
330.29 |
| Chemical Properties | Back Directory | [Melting point ]
259-260 °C | [Boiling point ]
619.0±55.0 °C(Predicted) | [density ]
1.483±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated), Pyridine (Slightly) | [form ]
Solid | [pka]
6.47±0.40(Predicted) | [color ]
Pale Yellow to Light Yellow | [Stability:]
Hygroscopic | [Major Application]
food and beverages | [InChI]
InChI=1S/C17H14O7/c1-22-13-5-8(3-4-9(13)18)12-6-10(19)15-14(24-12)7-11(20)17(23-2)16(15)21/h3-7,18,20-21H,1-2H3 | [InChIKey]
GLAAQZFBFGEBPS-UHFFFAOYSA-N | [SMILES]
C1(C2=CC=C(O)C(OC)=C2)OC2=CC(O)=C(OC)C(O)=C2C(=O)C=1 | [LogP]
1.300 (est) |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow crystalline powder, soluble in organic solvents such as methanol, ethanol, DMSO, etc., derived from mugwort leaves, long-leaf Arnica montana flowers, aerial parts of Artemisia annua, stevia, Rehmannia root leaves, and aerial parts of Cistanche deserticola. | [Uses]
Jaceosidin exhibits anti-allergic, anti-inflammatory and apoptosis inducing activities. | [Definition]
ChEBI: A trihydroxyflavone that is flavone with hydroxy groups at positions 5, 7 and 4' and methoxy groups at positions 3' and 6. Isolated from Salvia tomentosa and Artemisia asiatica, it exhibits anti-allergic, anti-inflammatory and apo
tosis inducing activties. | [in vivo]
Jaceosidin (10 and 20 mg/kg, p.o., once a day for 3 days) blocks carrageenan-induced increase in leukocyte number and protein levels in air pouch exudates in mice[3].
?
Jaceosidin (10, 20 mg/kg, p.o.) suppresses COX-2 expression and NF-κB activation in mice[3].
?
Jaceosidin (20 mg/kg, p.o. for 2 hours) reduces hind paw edema volume in rats[3]. | Animal Model: | 5-week-old male BALB/c mice (23-26 g)[3] | | Dosage: | 10 and 20 mg/kg | | Administration: | P.O. once a day for 3 days | | Result: | Decreased the volumes of exudates (inflammatory markers), cell number and protein levels. Inhibited TNF-α by 46.7% and 50.8%, IL-1β by 46.0% and 44.7%, and PGE2 by 21.7% and 16.9%, respectively, at 20 mg/kg. Blocked COX-2 expression and NF-κB activation. |
| Animal Model: | Male Sprague-Dawley rats (180-200 g)[3] | | Dosage: | 20 mg/kg | | Administration: | P.O., for 2 hour | | Result: | Reduced hind paw edema volume by 27.1% at 1 h, and 24.0% at 2 h, respectively. |
| [IC 50]
Bax; COX-2 |
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| Company Name: |
China Langchem Inc.
|
| Telephone: |
0086-21-58956006 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList19141/0_EN.htm |
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