| Identification | Back Directory | [Name]
Polygalasaponin XXXI | [CAS]
79103-90-5 | [Synonyms]
Onjisaponin F
Polygalasaponin XXX
Polygalasaponin XXXI
Onjisaponin F
Polygalasaponin XXXI
Olean-12-ene-23,28-dioic acid, 3-(β-D-glucopyranosyloxy)-2,27-dihydroxy-, 28-[O-D-apio-β-D-furanosyl-(1→3)-O-[O-α-L-arabinopyranosyl-(1→3)-β-D-xylopyranosyl-(1→4)]-O-6-deoxy-α-L-mannopyranosyl-(1→2)-6-deoxy-4-O-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propen-1-yl]-β-D-galactopyranosyl] ester, (2β,3β... | [Molecular Formula]
C75H112O36 | [MDL Number]
MFCD29904545 | [MOL File]
79103-90-5.mol | [Molecular Weight]
1589.69 |
| Chemical Properties | Back Directory | [density ]
1.53±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
Powder | [pka]
4.14±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Polygalasaponin XXXI (Onjisaponin F) is an effective adjuvant for intranasal administration of influenza Influenza hemagglutinin (HA) vaccine to protect influenza virus infection[1]. | [Definition]
ChEBI: Onjisaponin F is a triterpenoid saponin. | [in vivo]
Intranasal vaccination with Polygalasaponin XXXI (Onjisaponin F) inhibits proliferation of mouse adapted influenza virus A/PR/8/34 in bronchoalveolar lavages of infected mice[1]. | [target]
cAMP | [References]
[1] T Nagai, et al. Onjisaponins, From the Root of Polygala Tenuifolia Willdenow, as Effective Adjuvants for Nasal Influenza and Diphtheria-Pertussis-Tetanus Vaccines. Vaccine. 2001 Sep 14;19(32):4824-34. DOI:10.1016/s0264-410x(01)00215-8
[2] T Yabe, et al. Induction of NGF Synthesis in Astrocytes by Onjisaponins of Polygala Tenuifolia, Constituents of Kampo (Japanese Herbal) Medicine, Ninjin-yoei-to. Phytomedicine. 2003 Mar;10(2-3):106-14. DOI:10.1078/094471103321659799 |
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