| Identification | Back Directory | [Name]
Decapeptide-12 | [CAS]
137665-91-9 | [Synonyms]
Decapeptide-12
Decapeptide-12/ Lumixyl
Decapeptide-12 USP/EP/BP
Decapeptide-12 lumixyl / cosmetic peptide
L-Tyrosine, L-tyrosyl-L-arginyl-L-seryl-L-arginyl-L-lysyl-L-tyrosyl-L-seryl-L-seryl-L-tryptophyl- | [EINECS(EC#)]
-0 | [Molecular Formula]
C65H90N18O17 | [MDL Number]
MFCD00273671 | [MOL File]
137665-91-9.mol | [Molecular Weight]
1395.52 |
| Chemical Properties | Back Directory | [density ]
1.51±0.1 g/cm3(Predicted) | [pka]
3.07±0.10(Predicted) | [Sequence]
H-Tyr-Arg-Ser-Arg-Lys-Tyr-Ser-Ser-Trp-Tyr-OH | [Cosmetics Ingredients Functions]
SKIN CONDITIONING
BLEACHING | [InChIKey]
OYVFAMLECFSFEI-XJHNTGDTSA-N |
| Hazard Information | Back Directory | [Description]
Decapeptide-12 is an oligopeptide that is made up of just 10 amino acids. This oligopeptide is known for its anti-tyrosinase activity. Tyrosinase is accountable for producing melanin in the skin. Decapeptide 12 connects to tyrosinase and prevents it from catalyzing the oxidation of phenols – the initial step in melanin creation. It’s able to interfere with tyrosinase and lighten skin. | [Uses]
Decapeptide-12, a small oligopeptide, is a tyrosinase inhibitor that interacts with C-terminal residue of tyrosinase (Kd: 61.1 μM). Decapeptide-12 is a competitive inhibitor of mushroom tyrosinase (IC50: 40 μM). Decapeptide-12 also increases transcription of SIRT. Decapeptide-12 reduces melanin content in melanocytes. Decapeptide-12 is used for the research of melanogenesis, senescence, inflammation [1][2][3]. | [References]
[1] Anan Abu Ubeid, et al. Short-sequence oligopeptides with inhibitory activity against mushroom and human tyrosinase. J Invest Dermatol. 2009 Sep;129(9):2242-9. DOI:10.1038/jid.2009.124
[2] Akihito Ochiai, et al. New tyrosinase inhibitory decapeptide: Molecular insights into the role of tyrosine residues. J Biosci Bioeng. 2016 Jun;121(6):607-613. DOI:10.1016/j.jbiosc.2015.10.010
[3] Basil M H, et al. Tyrosinase inhibitors with potent anti-senescence activity in human neonatal keratinocyte progenitors. J Dermatol Surg Res Ther, 2019, 2019: 30-39. |
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