| Identification | More | [Name]
Nalpha-Fmoc-L-lysine hydrochloride | [CAS]
139262-23-0 | [Synonyms]
FMOC-L-LYSINE HYDROCHLORIDE
FMOC-LYSINE HCL
FMOC-LYS-OH HCL
Fmoc-Lys-OH hydrochloride
N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-L-LYSINE HYDROCHLORIDE
N-ALPHA-FMOC-L-LYSINE, HCL
N(ALPHA)-FMOC-L-LYSINE HYDROCHLORIDE
Nα-Fmoc-L-lysine hydrochloride
nα-fmoc-l-lysine hydrochloride
Fmoc-L-Lys-OH·HCl
Nalpha-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine Hydrochloride | [Molecular Formula]
C21H25ClN2O4 | [MDL Number]
MFCD00190889 | [Molecular Weight]
404.89 | [MOL File]
139262-23-0.mol |
| Questions And Answer | Back Directory | [Synthesis]
The protected amino acid derivative (2 mg) was placed in a 1.5 mL glass vial with a screw cap. The appropriate acid solution (1 mL) and 0.1 M HCl were added to the HFIP. The reaction mixture was incubated at room temperature for 240 min, and the product Fmoc-Lys-OH hydrochloride was obtained by RT-HPLC and MALDI-TOF or ESI HR mass spectrometry. |
| Chemical Properties | Back Directory | [refractive index ]
-11.0 ° (C=1, DMF) | [storage temp. ]
2-8°C
| [solubility ]
Soluble in dimethyl formamide (0.3g in 2ml). | [form ]
powder to crystal | [color ]
White to Almost white | [BRN ]
8663370 | [Major Application]
peptide synthesis | [InChIKey]
MVMZFAIUUXYFGY-FYZYNONXSA-N | [SMILES]
C(C1C2=CC=CC=C2C2C=CC=CC1=2)OC(=O)N[C@H](C(=O)O)CCCCN.Cl |&1:18,r| | [CAS DataBase Reference]
139262-23-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Description]
Fmoc-Lys-OH hydrochloride is a cleavable ADC linker used to synthesize antibody-drug conjugates (ADCs). Fmoc-Lys-OH hydrochloride is also an alkyl chain-based PROTAC linker that can be used to synthesize PROTACs.
| [Chemical Properties]
White solid | [Uses]
It is used as an active pharmaceutical intermediate and in the synthesis of nε-(7-diethylaminocoumarin-3-carboxyl)- and nε-(7-methoxycoumarin-3-carboxyl)-l-fmoc lysine as tools for protease cleavage detection by fluorescence. | [reaction suitability]
reaction type: Fmoc solid-phase peptide synthesis | [IC 50]
Non-cleavable Linker |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Alfa Aesar
|
| Telephone: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Telephone: |
400-0056266 |
| Website: |
www.energy-chemical.com |
|