| Identification | Back Directory | [Name]
1-Boc-4-[methoxy(methyl)carbamoyl]piperidine | [CAS]
139290-70-3 | [Synonyms]
N-BOC-4-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE
1-BOC-4-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE
1-Boc-4-(N-Methoxy-N-MethylcarbaMoyl)piperidine
1-Boc-N-methoxy-N-methyl-4-piperidinecarboxamide
N’-Boc-N-methoxy-N-methylpiperidine-4-carboxamide
4-[Methoxy(methyl)carbamoyl]piperidine, N1-BOC protected
4-[(MethoxyMethylaMino)carbonyl]-1-piperidinecarboxylic Acid
4-[Methoxy(methyl)carbamoyl]piperidine, N1-BOC protected 98%
1-(tert-Butoxycarbonyl)-4-(N-methoxy-N-methylcarbamoyl)piperid
tert-Butyl 4-[Methoxy(Methyl)-carbaMoyl]piperidin-1-carboxylate
tert-Butyl 4-[methoxy(methyl)carbamoyl]piperidine-1-carboxylate
tert-Butyl 4-(N-Methoxy-N-MethylcarbaMoyl)-1-piperidinecarboxylate
TERT-BUTYL 4-(N-METHOXY-N-METHYLCARBAMOYL)PIPERIDINE-1-CARBOXYLATE
1-(tert-Butoxycarbonyl)-N-methoxy-N-methyl-4-piperidinecarboxamide
tert-Butyl 4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylate >
4-(Methoxy-methyl-carbamoyl)-piperidine-1-carboxylicacidtert-butylester
1,1-Dimethylethyl 4-[[methyl(methoxy)amino]carbonyl]-1-piperidinecarboxylate
4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylic Acid tert-Butyl Ester
1-Piperidinecarboxylic acid, 4-[(methoxymethylamino)carbonyl]-, 1,1-dimethylethyl ester
tert-Butyl 4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylate
4-(N-Methoxy-N-methylcarbamoyl)-1-piperidinecarboxylic Acid tert-Butyl Ester
1-(tert-Butoxycarbonyl)-N-methoxy-N-methyl-4-piperidinecarboxamide
1-Boc-N-methoxy-N-methyl-4-piperidinecarboxamide
1-(tert-Butoxycarbonyl)-4-(N-methoxy-N-methylcarbamoyl)piperid | [Molecular Formula]
C13H24N2O4 | [MDL Number]
MFCD07368262 | [MOL File]
139290-70-3.mol | [Molecular Weight]
272.34 |
| Chemical Properties | Back Directory | [Melting point ]
71.0 to 75.0 °C | [Boiling point ]
150°C/0.9mmHg(lit.) | [density ]
1.106±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform, Dichloromethane, Ethyl Acetate, Methanol | [form ]
Oil | [pka]
-2.31±0.40(Predicted) | [color ]
Pale Yellow | [InChI]
InChI=1S/C13H24N2O4/c1-13(2,3)19-12(17)15-8-6-10(7-9-15)11(16)14(4)18-5/h10H,6-9H2,1-5H3 | [InChIKey]
ITCQNWXLNZGEHP-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCC(C(N(OC)C)=O)CC1 |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Oil | [Uses]
An intermediate in the production of IKK inhibitors, ERK inhibitors, p38 MAP kinase inhibitors and serotonin receptor antagonists | [Synthesis]
The general procedure for the preparation of 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine from 1-Boc-4-piperidinecarboxylic acid (2.34 g, 10.2 mmol) and dimethylhydroxylamine hydrochloride (1.5 g, 15 mmol) in DMF (50 mL) was as follows: to a stirred 1-Boc-4-piperidinecarboxylic acid and dimethylhydroxylamine hydrochloride at room temperature in a suspension in DMF was added triethylamine (2.8 mL, 20 mmol). After stirring for 10 min, HOBt (1.62 g, 12 mmol) and EDCI (2.3 g, 12 mmol) were added sequentially. The reaction mixture was stirred overnight and subsequently concentrated. The concentrated residue was dissolved in 1N HCl (100 mL) and extracted with EtOAc (3 × 100 mL). The organic phases were combined, washed sequentially with saturated NaHCO3 solution (50 mL), brine (50 mL), dried over MgSO4 and concentrated to give a colorless oily product (2.79 g, yield >100%). The product was characterized by 1H NMR (500 MHz, CDCl3) and MS (ESI+): 1H NMR δ 4.14 (m, 2H), 3.71 (s, 3H), 3.19 (s, 3H), 2.78 (m, 3H), 1.68 (m, 4H), 1.46 (s, 9H); MS (ESI+) m/z 217.72 (M+H+- Isobutene). | [References]
[1] Patent: US2004/14763, 2004, A1. Location in patent: Page 21
[2] Patent: WO2008/17461, 2008, A1. Location in patent: Page/Page column 61-62
[3] Patent: WO2008/108957, 2008, A2. Location in patent: Page/Page column 38
[4] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 4, p. 935 - 939
[5] Patent: WO2006/2434, 2006, A2. Location in patent: Page/Page column 39 |
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