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BAN ORL 24 Dihydrochloride, is a potent and selective KOR-3 (NOP) antagonist. It inhibits nociceptin-induced stimulation of [35S]-GTPγS binding and Ca2+ mobilization in CHO cells in vitro and antagonizes NOP agonist-induced reduction in locomotor activity in vivo. | [in vivo]
BAN ORL 24 (10 mg/kg; i.v.) attenuates the duration of BPRIM97 thermal antinociception[3]. | Animal Model: | C57BL/6 mice[3] | | Dosage: | 10 mg/kg | | Administration: | 10 mg/kg; i.v. | | Result: | Caused inhibition of BPRIM97-induced antinociception at 90-min postinjection.
Did not attenuate BPR1M97-induced antinociception in the tail-clip test after 30 min.
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| [IC 50]
NOP Receptor/ORL1 |
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| Company Name: |
InvivoChem
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| Telephone: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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