| Chemical Properties | Back Directory | [Boiling point ]
1076.8±65.0 °C(Predicted) | [density ]
1.285±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Chloroform: Soluble; Ethanol: Soluble; Methanol: Soluble | [form ]
Pale white solid. | [pka]
7.54±0.70(Predicted) | [color ]
Pale white |
| Hazard Information | Back Directory | [Description]
NG 012 is a fungal metabolite originally isolated from P. verruculosum that has fungicidal and nerve growth factor-potentiating properties. It inhibits the growth of the plant pathogenic fungi B. cinerea, P. teres, P. lingam, S. sclerotiorum, and M. fructigena in vitro. NG 012 (50 μM) increases the efficacy of the antifungal miconazole against C. albicans, reducing the IC50 value from 19.2 to 2.5 μM. It also potentiates neurite outgrowth induced by nerve growth factor (NGF) in PC12 cells in a concentration-dependent manner. | [Uses]
NG 012 is a novel form of nerve growth factor potentiator. | [storage]
Store at -20°C | [References]
[1] J BREINHOLT. Antifungal macrocyclic polylactones from Penicillium verruculosum.[J]. Journal of Antibiotics, 1993, 46 7: 1101-1108. DOI: 10.7164/antibiotics.46.1101
[2] M ITO. NG-011 and NG-012, novel potentiators of nerve growth factor. I. Taxonomy, isolation, and physico-chemical and biological properties.[J]. Journal of Antibiotics, 1992, 45 10: 1559-1565. DOI: 10.7164/antibiotics.45.1559
[3] MASAYOSHI ARAI. ChemInform Abstract: Funicone-Related Compounds, Potentiators of Antifungal Miconazole Activity, Produced by Talaromyces flavus FKI-0076.[J]. ChemInform, 2010, 33 33. DOI: 10.1002/chin.200233247 |
|
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|