| Identification | More | [Name]
Niclosamide ethanolamine salt | [CAS]
1420-04-8 | [Synonyms]
NICLOSAMIDEL
clonitralid
Luomiecide
Mollutox
Niclosamide ethanolamine salt
Phenasal ethanolamine salt
Ethanolamine salt Niclosamide
Bayluscid[R]
Clonitralide
NICLOSAMIDE ETHANOLAMINE
2'',5-DICHLORO-4''-NITROSALICYLANILIDE(NICLOSAMIDE)
BAYER73
2',5-Dichloro-4'-nitrosalicylanilide 2-aminoethanol salt
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide 2-aminoethanol salt
Snanilcide
2',5-Dichloro-4'-nitrosalicyloylanilide ethanolamine salt
5,2-Dichloro-4-nitrosalicylic anilide 2-aminoethanol salt
5-Chloro-n-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compd with 2-aminoethanol
Ethanolamine salt of 5,2'-dichloro-4'-nitrosalicyclicanilide
Hl 2448 | [EINECS(EC#)]
215-811-7 | [Molecular Formula]
C15H15Cl2N3O5 | [MDL Number]
MFCD01941566 | [Molecular Weight]
388.2 | [MOL File]
1420-04-8.mol |
| Chemical Properties | Back Directory | [Appearance]
Depending on purity, a bright yellow or brownish-yellow crystalline solid or powder. Odorless. Soluble in water | [Melting point ]
204° | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMF: 30 mg/mL; DMSO: 30 mg/mL; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL; Ethanol: 0.25 mg/mL | [form ]
A crystalline solid | [color ]
Light yellow to yellow | [Stability:]
Stable. Hydrolyzes in concentrated acidic or basic solutions. | [Henry's Law Constant]
2.6×104 mol/(m3Pa) at 25℃, HSDB (2015) | [CAS DataBase Reference]
1420-04-8(CAS DataBase Reference) | [EPA Substance Registry System]
1420-04-8(EPA Substance) |
| Hazard Information | Back Directory | [General Description]
Yellow solid. Insoluble in water. | [Reactivity Profile]
CLONITRALID(1420-04-8) is hydrolyzed by concentrated acid or alkali. | [Air & Water Reactions]
Insoluble in water. | [Potential Exposure]
Niclosamide, the parent chemical, is a relatively selective, noncumulative chlorinated aromatic amide pesticide. Clonitralid (ethanolamine salt of niclosamide) is used principally against molluscs, especially fresh water snails and to control sea lamprey larvae and also as an antiparasitic drug in human, pets, and livestock. Niclosamide is toxic to all fish species at 0.5 mg/L (48 hours). A restricted use pesticide in the United States. Limited to use by a certified applicator . Not listed for use in EU countries. | [Fire Hazard]
Flash point data for this chemical are not available. CLONITRALID is probably combustible. | [First aid]
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. Give artificial respiration if victim is not breathing. Do not use mouthto-mouth method if victim ingested or inhaled the substance; give artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult. Remove and isolate contaminated clothing and shoes. In case of contact with substance, immediately flush skin or eyes with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin. Keep victim warm and quiet. Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed. Ensure that medical personnel are aware of the material(s) involved and take precautions to protect themselves. | [Shipping]
UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2902 Pesticides, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. | [Incompatibilities]
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Hydrolyzed by strong acids, and alkalies. Slowly hydrolyzes in water, releasing ammonia and forming acetate salts. Decomposes at B200-205°C. | [Chemical Properties]
Depending on purity, a bright yellow or brownish-yellow crystalline solid or powder. Odorless. Soluble in water | [Waste Disposal]
Do not discharge into drains or sewers. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Burn in incinerator specifically designed for pesticide disposal or dispose as a hazardous waste in a landfill approved and licensed for the disposal of pesticides. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Ultimate disposal of the chemical must consider: the material’s impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations | [Uses]
The ethanolamine salt as a molluscicide. | [Production Methods]
The production of niclosamide-olamine begins with the synthesis of niclosamide, typically via a condensation reaction between 5-chlorosalicylic acid and 2-chloro-4-nitroaniline in the presence of a chlorinating agent such as phosphorus trichloride, often carried out in a solvent like chlorobenzene at elevated temperatures. The resulting niclosamide is then purified through recrystallisation. To form the ethanolamine salt (niclosamide-olamine), niclosamide is reacted with monoethanolamine under controlled pH and temperature conditions, producing a more water-soluble and bioavailable compound suitable for veterinary formulations. | [Agricultural Uses]
Molluscicide: Niclosamide, the parent chemical, is a relatively
selective, non-cumulative chlorinated aromatic amide pesticide. Clonitralid (ethanolamine salt of Niclosamide) is
used principally against molluscs, especially fresh water
snails and to control sea lamprey larvae and also as an antiparasitic drug in human, pets and livestock. Niclosamide is
toxic to all fish species at 0.5 mg/L (48 hours). A U.S. EPA
restricted Use Pesticide as Niclosamide. Limited to use by
a certified applicator [40 CFR 152.175 (a) (7/1/94)]. Not
listed for use in EU countries. Registered for use in
the U.S. | [Trade name]
BAY 73® and U.S. Fish and Wildlife
Service; BAY 6076®; BAYER 73®; BAYER 25648®;
BAYLUSCID®[C]; BAYLUSCIDE® and U.S. Fish and
Wildlife Service; M 73®; MOLLUSCICIDE BAYER
73®; NICLOSAMIDE®; SR 73® | [Biological Activity]
Cell permeable: yes | [Mechanism of action]
Respiratory & stomach action. Acts by uncoupling oxidative phosphorylation in the tapeworm | [Pesticide Type]
Fungicide; Molluscicide; Nematicide; Veterinary substance; Teniacide |
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