| Identification | Back Directory | [Name]
free base case | [CAS]
1428064-91-8 | [Synonyms]
Teplinovivint
N-(6-methoxypyridin-3-yl)-5-(5-(piperidin-1-ylmethyl)pyridin-3-yl)-1H-indazole-3-carboxamide
inhibit,Inhibitor,stem,Tenomodulin,SW480,β-catenin,mesenchymal,hMSCs,colorectal,SCXA,Teplinovivint,TenacinC,Wnt,Beta catenin | [Molecular Formula]
C25H26N6O2 | [MDL Number]
MFCD30489371 | [MOL File]
1428064-91-8.mol | [Molecular Weight]
442.51 |
| Chemical Properties | Back Directory | [Boiling point ]
607.6±55.0 °C(Predicted) | [density ]
1.316±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 83.33 mg/mL (188.31 mM; Need ultrasonic) | [form ]
Solid | [pka]
10.32±0.70(Predicted) | [color ]
Light brown to khaki |
| Hazard Information | Back Directory | [Uses]
Teplinovivint is a potent wnt/β-catenin signaling pathway inhibitor. Teplinovivint has anti-inflammatory activity and has the potential for tendinopathy research[1]. | [in vivo]
Teplinovivint (compound 175; 10 mg/ml; once daily for 21 days via topical application) causes amelioration of inflammation as well as tendon degeneration. Teplinovivint results in a decrease of aninflammatory plasma biomarker, KC/GRO in the Collagenase-induced Tendon Injury Model[1].
Teplinovivint (1 mg/ml with 1% BA) has a Tmax of 1 hours in plasma[1].
| [storage]
Store at -20°C | [References]
[1] Vishal DESHMUKH, et al. Methods of using indazole-3-carboxamides and their use as wnt/b-catenin signaling pathway inhibitors. WO2018075858A1. |
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| Company Name: |
Biorbyt Ltd.
|
| Tel: |
+44 (0)1223 859 353 |
| Website: |
http://www.biorbyt.com |
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