| Identification | More | [Name]
Sulfathiazole sodium | [CAS]
144-74-1 | [Synonyms]
4-AMINO-N-2-THIAZOLYBENZENESULFONAMIDE SODIUM SALT
4-AMINO-N-(2-THIAZOLYL)BENZENESULFONAMIDE SODIUM SALT
LABOTEST-BB LT00772308
SODIUM SULFATHIAZOLE
SULFATHIAZOLE
SULFATHIAZOLE SODIUM
SULFATHIAZOLE SODIUM SALT
thiazamide
(n(sup1)-2-thiazolylsulfanilamido)-sodiu
2-sulfanilamidothiazolesodiumsalt
4-amino-n-2-thiazolyl-benzenesulfonamidmonosodiumsalt
monosodium2-sulfanilamidothiazole
n(sup1)-2-thiazolylsulfanilamidesodiumsalt
n(sup1)-2-thiazolyl-sulfanilamidmonosodiumsalt
n(sup1)-2-thiazolyl-sulfanilamidn(sup1)-sodiumderiv.
sodium2-sulfanilamidothiazole
sodiumnorsulfazole
sodiumsulphathiazole
solublesulfathiazole
ST-NA | [EINECS(EC#)]
205-638-5 | [Molecular Formula]
C9H9N3NaO2S2 | [MDL Number]
MFCD00072133 | [Molecular Weight]
278.31 | [MOL File]
144-74-1.mol |
| Chemical Properties | Back Directory | [storage temp. ]
Store at -20°C | [solubility ]
H2O: soluble50mg/mL | [form ]
powder | [color ]
white to off-white | [biological source]
synthetic (Organic) | [Water Solubility ]
H2O: soluble 50mg/mL | [BRN ]
3802297 | [Stability:]
Hygroscopic | [InChI]
InChI=1S/C9H9N3O2S2.Na.H/c10-7-1-3-8(4-2-7)16(13,14)12-9-11-5-6-15-9;;/h1-6H,10H2,(H,11,12);; | [InChIKey]
PLYRQFRFHFKJLU-UHFFFAOYSA-N | [SMILES]
S(C1C=CC(N)=CC=1)(=O)(=O)NC1SC=CN=1.[NaH] | [CAS DataBase Reference]
144-74-1(CAS DataBase Reference) | [EPA Substance Registry System]
144-74-1(EPA Substance) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H315-H319-H335 | [Precautionary statements ]
P261-P264-P271-P280-P302+P352-P305+P351+P338 | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) . | [WGK Germany ]
2
| [RTECS ]
WP2450000
| [F ]
10 | [TSCA ]
TSCA listed | [REACH Registrations]
Active | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| Hazard Information | Back Directory | [Description]
Sulfathiazole sodium salt is a short-acting sulfa drug. It was a common oral and topical antibiotic until less toxic alternatives were discovered. It is no longer used in humans. Sulfathiazole is added to the diet of laboratory animals to inhibit folate formation by gut bacteria. This ensures that the animal′s only source of available folate is from their diet. Sulfathiazole is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfathiazole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis. | [Uses]
Sulfathiazole sodium salt is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA). It can also be used in biological study of thermotherapy and sulfonamide antibiotics deciphered Cyanobacteria and Proteobacteria microbiome in huanglongbing-affected Citrus paradise and Citrus limon. | [General Description]
Chemical structure: sulfonamide | [Biochem/physiol Actions]
Sulfathiazole is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfathiazole is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis. |
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