| Identification | Back Directory | [Name]
Bromo-PEG5-phosphonic acid ethyl ester | [CAS]
1446282-41-2 | [Synonyms]
Bromo-peg5-ethyl phosphate
Bromo-PEG5-phosphonic acid ethyl ester
Bromo-PEG5-phosphonic acid diethyl ester
Phosphonic acid, P-(17-bromo-3,6,9,12,15-pentaoxaheptadec-1-yl)-, diethyl ester | [Molecular Formula]
C16H34BrO8P | [MDL Number]
MFCD25424122 | [MOL File]
1446282-41-2.mol | [Molecular Weight]
465.31 |
| Hazard Information | Back Directory | [Description]
Bromo-PEG5-phosphonic acid diethyl ester is a PEG linker containing a bromine and a hydrophilic PEG chain. The size and electronegative properties of bromine make it a good leaving group and able to participate in substitution reactions. The hydrophilic PEG linker increases the compound's solubility in aqueous media. | [Uses]
Bromo-PEG5-phosphonic acid diethyl ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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