| Identification | Back Directory | [Name]
Bromo-PEG4-t-butyl ester | [CAS]
564476-32-0 | [Synonyms]
564476-32-0
Br-PEG4-COOtBu
Br-PEG4-C2-Boc
CAS_564476-32-0
Br-PEG4-CH2CH2COOtBu
Br-PEG4-t-butyl ester
Bromo-PEG4-t-butyl ester
Bromo-PEG5-t-butyl ester
4,7,10,13-Tetraoxapentadecanoic acid, 15-bromo-, 1,1-dimethylethyl ester
3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-bromo-, 1,1-dimethylethylester | [Molecular Formula]
C15H29BrO6 | [MDL Number]
MFCD22574808 | [MOL File]
564476-32-0.mol | [Molecular Weight]
385.29 |
| Chemical Properties | Back Directory | [Boiling point ]
415.8±35.0 °C(Predicted) | [density ]
1.210±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DMSO, DCM, DMF | [form ]
Liquid | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Bromo-PEG4-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Br-PEG4-C2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. | [Biological Activity]
Br-PEG4-C2-Boc is a cleavable ADC linker containing 4 units of PEG, which can be used to synthesize antibody drug conjugates (ADC). | [target]
| Cleavable | PEGs | Alkyl/ether | | [IC 50]
Cleavable Linker; PEGs; Alkyl/ether | [References]
[1] Robert Yongxin Zhao, et al. Cytotoxic agents. WO2003068144A2. |
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