| Identification | Back Directory | [Name]
Bromo-PEG1-t-butyl ester | [CAS]
1393330-36-3 | [Synonyms]
1393330-36-3
CAS_1393330-36-3
Bromo-PEG1-C2-Boc
Br-PEG1-CH2CH2COOtBu
Bromo-PEG1-t-butyl ester
tert-Butyl 3-(2-bromoethoxy)propanoate
Propanoic acid, 3-(2-bromoethoxy)-, 1,1-dimethylethyl ester | [Molecular Formula]
C9H17BrO3 | [MDL Number]
MFCD22574803 | [MOL File]
1393330-36-3.mol | [Molecular Weight]
253.13 |
| Chemical Properties | Back Directory | [Boiling point ]
285.0±15.0 °C(Predicted) | [density ]
1.264±0.06 g/cm3(Predicted) | [solubility ]
Soluble in DCM, Hexane | [form ]
Liquid | [color ]
Colorless to light yellow | [InChI]
InChI=1S/C9H17BrO3/c1-9(2,3)13-8(11)4-6-12-7-5-10/h4-7H2,1-3H3 | [InChIKey]
KRGOEVTUVNSLIG-UHFFFAOYSA-N | [SMILES]
C(OC(C)(C)C)(=O)CCOCCBr |
| Hazard Information | Back Directory | [Description]
Bromo-PEG1-t-butyl ester is a PEG linker containing a bromide group and a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | [Uses]
Bromo-PEG1-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs; Alkyl/ether | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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