| Identification | More | [Name]
Rizatriptan benzoate | [CAS]
145202-66-0 | [Synonyms]
MAXALT
MK-0462
MK-462
n,n-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl]ethylamine benzoate
N,N-DIMETHYL-5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOLE-3-ETHANAMINE, BENZOATE
RIZATRIPTAN BENZOATE
RIZATRIPTANE BENZOATE
Rizatrimptan Benzoate
Rizatrimptan
Rizatriptan monobenzoate
N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-
Rizatriptan benzoate,MaxaLt | [EINECS(EC#)]
604-465-6 | [Molecular Formula]
C22H25N5O2 | [MDL Number]
MFCD00866224 | [Molecular Weight]
391.47 | [MOL File]
145202-66-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
178-180°C | [storage temp. ]
2-8°C | [solubility ]
H2O: ≥5mg/mL | [form ]
powder | [color ]
white to beige | [Water Solubility ]
H2O: ≥5mg/mL | [Usage]
A selective serotonin 5-HTID receptor agonist. Structurally derived from tryptamine | [Merck ]
14,8241 | [InChI]
InChI=1S/C15H19N5.C7H6O2/c1-19(2)6-5-13-8-17-15-4-3-12(7-14(13)15)9-20-11-16-10-18-20;8-7(9)6-4-2-1-3-5-6/h3-4,7-8,10-11,17H,5-6,9H2,1-2H3;1-5H,(H,8,9) | [InChIKey]
JPRXYLQNJJVCMZ-UHFFFAOYSA-N | [SMILES]
C(C1C=CC=CC=1)(=O)O.C(C1=CNC2C=CC(CN3N=CN=C3)=CC1=2)CN(C)C | [CAS DataBase Reference]
145202-66-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS08 | [Signal word ]
Danger | [Hazard statements ]
H360 | [Precautionary statements ]
P201-P308+P313 | [Hazard Codes ]
T | [Risk Statements ]
61 | [WGK Germany ]
3 | [HS Code ]
2933995500 | [Storage Class]
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | [Hazard Classifications]
Repr. 1B |
| Questions And Answer | Back Directory | [Description]
Known as a 5-hydroxytryptamine agonist, Rizatriptan Benzoate is the benzoate salt form of rizatriptan with anti-migraine activity, which can be used to treat the migraine headaches. It is FDA-approved to use in the treatment of acute migraine attacks with or without aura, especially taken at the first sign of a migraine headache. However, it cannot prevent future migraine attacks and it is ineffective to prevent other types of headache.
The pain of migraine headaches is believed to be induced by dilated blood vessels inside the head. Rizatriptan Benzoate relieves the pain by inducing vasoconstriction, which functions as an agonist at serotonin 5-HT1B and 5-HT1D receptors. The selective receptor binding is effective to constrict cranial vessels and inhibit the transmission of nociception, thus providing relief of migraine headaches.
| [References]
https://en.wikipedia.org/wiki/Rizatriptan
https://pubchem.ncbi.nlm.nih.gov/compound/77997#section=Top
http://bodyandhealth.canada.com/drug/getdrug/co-rizatriptan-odt
|
| Hazard Information | Back Directory | [Chemical Properties]
Off-White Solid | [Originator]
Merck & Co (US) | [Uses]
A selective serotonin 5-HTID receptor agonist. Structurally derived from tryptamine | [Uses]
Rizatriptan Benzoate(Maxalt) is a 5-HT1 agonist triptan drug for the treatment of migraine headaches. It is believed to work by narrowing the blood vessels around the brain. Rizatriptan also reduces the substances in the body, which can also reduce headac | [Definition]
ChEBI: Rizatriptan benzoate is a member of tryptamines. | [Brand name]
Maxalt (Merck). | [General Description]
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards | [Biochem/physiol Actions]
Rizatriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. | [Synthesis]
A method for the preparation of rizatriptan benzoate, characterized in that it is carried out in the following steps: ① using 4-chlorobutanal as a raw material, and reacting with sodium metabisulfite in an addition reaction to obtain sodium 4-chlorobutane |
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| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Simagchem Corp.
|
| Telephone: |
86 592 2680277 |
| Website: |
www.simagchem.com |
|